GABRE explained

Gamma-aminobutyric acid receptor subunit epsilon is a protein that in humans is encoded by the GABRE gene.^{[1] [2] [3]}

The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants encoding different isoforms have been identified.

Brainstem expression of ε subunit-containing GABA_A receptors is upregulated during pregnancy, particularly in the ventral respiratory group.^[4]

See also

• GABAA receptor

Further reading

• Jones BL, Henderson LP . Trafficking and potential assembly patterns of epsilon-containing GABAA receptors . J. Neurochem. . 103 . 3 . 1258–1271 . 2007 . 17714454 . 10.1111/j.1471-4159.2007.04833.x . 85020515 .
• Rosen A, Bali M, Horenstein J, Akabas MH . Channel opening by anesthetics and GABA induces similar changes in the GABAA receptor M2 segment . Biophys. J. . 92 . 9 . 3130–3139 . 2007 . 17293408 . 10.1529/biophysj.106.094490 . 1852347 . 2007BpJ....92.3130R .
• Wilkins ME, Hosie AM, Smart TG . Proton modulation of recombinant GABA(A) receptors: influence of GABA concentration and the beta subunit TM2-TM3 domain . J. Physiol. . 567 . Pt 2 . 365–377 . 2005 . 15946973 . 10.1113/jphysiol.2005.088823 . 1474194 .
• Porter BE, Zhang G, Celix J . Heterogeneous GABAA receptor subunit expression in pediatric epilepsy patients . Neurobiol. Dis. . 18 . 3 . 484–491 . 2005 . 15755675 . 10.1016/j.nbd.2004.12.010 . 10973066 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–45 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Davies PA, McCartney MR, Wang W . Alternative transcripts of the GABA(A) receptor epsilon subunit in human and rat . Neuropharmacology . 43 . 4 . 467–475 . 2002 . 12367593 . 10.1016/S0028-3908(02)00153-3 . 54340902 . etal.
• Sinkkonen ST, Hanna MC, Kirkness EF, Korpi ER . GABA(A) receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus . J. Neurosci. . 20 . 10 . 3588–3595 . 2000 . 10804200 . 10.1523/jneurosci.20-10-03588.2000. 6772669 . free .
• Russek SJ . Evolution of GABA(A) receptor diversity in the human genome . Gene . 227 . 2 . 213–222 . 1999 . 10023064 . 10.1016/S0378-1119(98)00594-0 .
• Wilke K, Gaul R, Klauck SM, Poustka A . A gene in human chromosome band Xq28 (GABRE) defines a putative new subunit class of the GABAA neurotransmitter receptor . Genomics . 45 . 1 . 1–10 . 1997 . 9339354 . 10.1006/geno.1997.4885 .
• Whiting PJ, McAllister G, Vassilatis D . Neuronally restricted RNA splicing regulates the expression of a novel GABAA receptor subunit conferring atypical functional properties [corrected; erratum to be published] . J. Neurosci. . 17 . 13 . 5027–5037 . 1997 . 9185540 . 10.1523/jneurosci.17-13-05027.1997. 6573323 . etal. free .

Notes and References

1. Davies PA, Hanna MC, Hales TG, Kirkness EF . Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit . Nature . 385 . 6619 . 820–823 . Mar 1997 . 9039914 . 10.1038/385820a0 . 1997Natur.385..820D . 4241881 .
2. Garret M, Bascles L, Boue-Grabot E, Sartor P, Charron G, Bloch B, Margolskee RF . An mRNA encoding a putative GABA-gated chloride channel is expressed in the human cardiac conduction system . J Neurochem . 68 . 4 . 1382–1389 . Apr 1997 . 9084408 . 10.1046/j.1471-4159.1997.68041382.x . free .
3. Web site: Entrez Gene: GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon.
4. 22303446 . 10.1371/journal.pone.0030608 . 7 . Increased GABA(A) receptor ε-subunit expression on ventral respiratory column neurons protects breathing during pregnancy . 3269439 . 2012 . PLOS ONE . e30608 . Hengen KB, Nelson NR, Stang KM, Johnson SM, Crader SM, Watters JJ, Mitchell GS, Behan M. 1 . free . 2012PLoSO...730608H .