GABBR2 explained

Gamma-aminobutyric acid (GABA) B receptor, 2 (GABA_B2) is a G-protein coupled receptor subunit encoded by the GABBR2 gene in humans.^[1]

Function

B-type receptors for the neurotransmitter GABA (gamma-aminobutyric acid) inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters and the activity of ion channels and adenylyl cyclase. See GABBR1 (MIM 603540) for additional background information on GABA-B receptors.[supplied by OMIM]

Interactions

GABBR2 has been shown to interact with GABBR1.^[2]

See also

• GABAB receptor

Further reading

• White JH, Wise A, Main MJ, Green A, Fraser NJ, Disney GH, Barnes AA, Emson P, Foord SM, Marshall FH . Heterodimerization is required for the formation of a functional GABA(B) receptor . Nature . 396 . 6712 . 679–82 . 1999 . 9872316 . 10.1038/25354 . 1998Natur.396..679W . 4406311 .
• Ng GY, Clark J, Coulombe N, Ethier N, Hebert TE, Sullivan R, Kargman S, Chateauneuf A, Tsukamoto N, McDonald T, Whiting P, Mezey E, Johnson MP, Liu Q, Kolakowski LF, Evans JF, Bonner TI, O'Neill GP . Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity . J. Biol. Chem. . 274 . 12 . 7607–10 . 1999 . 10075644 . 10.1074/jbc.274.12.7607 . free .
• Ng GY, McDonald T, Bonnert T, Rigby M, Heavens R, Whiting P, Chateauneuf A, Coulombe N, Kargman S, Caskey T, Evans J, O'neill GP, Liu Q . Cloning of a novel G-protein-coupled receptor GPR 51 resembling GABAB receptors expressed predominantly in nervous tissues and mapped proximal to the hereditary sensory neuropathy type 1 locus on chromosome 9 . Genomics . 56 . 3 . 288–95 . 1999 . 10087195 . 10.1006/geno.1998.5706 .
• Martin SC, Russek SJ, Farb DH . Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1 . Mol. Cell. Neurosci. . 13 . 3 . 180–91 . 1999 . 10328880 . 10.1006/mcne.1999.0741 . 41258603 . free .
• Clark JA, Mezey E, Lam AS, Bonner TI . Distribution of the GABA(B) receptor subunit gb2 in rat CNS . Brain Res. . 860 . 1–2 . 41–52 . 2000 . 10727622 . 10.1016/S0006-8993(00)01958-2 . 19334154 .
• Sullivan R, Chateauneuf A, Coulombe N, Kolakowski LF, Johnson MP, Hebert TE, Ethier N, Belley M, Metters K, Abramovitz M, O'Neill GP, Ng GY . Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor . J. Pharmacol. Exp. Ther. . 293 . 2 . 460–7 . 2000 . 10773016 .
• White JH, McIllhinney RA, Wise A, Ciruela F, Chan WY, Emson PC, Billinton A, Marshall FH . The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx . Proc. Natl. Acad. Sci. U.S.A. . 97 . 25 . 13967–72 . 2001 . 11087824 . 17684 . 10.1073/pnas.240452197 . 2000PNAS...9713967W . free .
• Kitano J, Kimura K, Yamazaki Y, Soda T, Shigemoto R, Nakajima Y, Nakanishi S . Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins . J. Neurosci. . 22 . 4 . 1280–9 . 2002 . 11850456 . 6757580 . 10.1523/JNEUROSCI.22-04-01280.2002.
• Salim K, Fenton T, Bacha J, Urien-Rodriguez H, Bonnert T, Skynner HA, Watts E, Kerby J, Heald A, Beer M, McAllister G, Guest PC . Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation . J. Biol. Chem. . 277 . 18 . 15482–5 . 2002 . 11854302 . 10.1074/jbc.M201539200 . free .
• Furtinger S, Pirker S, Czech T, Baumgartner C, Sperk G . Increased expression of gamma-aminobutyric acid type B receptors in the hippocampus of patients with temporal lobe epilepsy . Neurosci. Lett. . 352 . 2 . 141–5 . 2004 . 14625043 . 10.1016/j.neulet.2003.08.046 . 54327057 .
• Waldvogel HJ, Billinton A, White JH, Emson PC, Faull RL . Comparative cellular distribution of GABAA and GABAB receptors in the human basal ganglia: immunohistochemical colocalization of the alpha 1 subunit of the GABAA receptor, and the GABABR1 and GABABR2 receptor subunits . J. Comp. Neurol. . 470 . 4 . 339–56 . 2004 . 14961561 . 10.1002/cne.20005 . 23646882 .
• Balasubramanian S, Teissére JA, Raju DV, Hall RA . Hetero-oligomerization between GABAA and GABAB receptors regulates GABAB receptor trafficking . J. Biol. Chem. . 279 . 18 . 18840–50 . 2004 . 14966130 . 10.1074/jbc.M313470200 . free .
• Uezono Y, Kaibara M, Hayashi H, Kawakami S, Enjoji A, Kanematsu T, Taniyama K . Characterization of GABAB receptor in the human colon . J. Pharmacol. Sci. . 94 . 2 . 211–3 . 2004 . 14978362 . 10.1254/jphs.94.211 . free .
• Hlavackova V, Goudet C, Kniazeff J, Zikova A, Maurel D, Vol C, Trojanova J, Prézeau L, Pin JP, Blahos J . Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR . EMBO J. . 24 . 3 . 499–509 . 2005 . 15660124 . 548662 . 10.1038/sj.emboj.7600557 .
• DeGiorgis JA, Jaffe H, Moreira JE, Carlotti CG, Leite JP, Pant HC, Dosemeci A . Phosphoproteomic analysis of synaptosomes from human cerebral cortex . J. Proteome Res. . 4 . 2 . 306–15 . 2005 . 15822905 . 10.1021/pr0498436 .
• Huda Zoghbi . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Osawa Y, Xu D, Sternberg D, Sonett JR, D'Armiento J, Panettieri RA, Emala CW . Functional expression of the GABAB receptor in human airway smooth muscle . Am. J. Physiol. Lung Cell Mol. Physiol. . 291 . 5 . L923–31 . 2006 . 16829628 . 10.1152/ajplung.00185.2006 .

External links

• Web site: GABA_B Receptors: GABA_B2 . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology .

Notes and References

1. Web site: Entrez Gene: GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2.
2. White JH, Wise A, Main MJ, Green A, Fraser NJ, Disney GH, Barnes AA, Emson P, Foord SM, Marshall FH . Heterodimerization is required for the formation of a functional GABA(B) receptor . . 396 . 6712 . 679–82 . Dec 1998 . 9872316 . 10.1038/25354 . 1998Natur.396..679W . 4406311 .