GABBR1 explained

Gamma-aminobutyric acid B receptor, 1 (GABA_B1), is a G-protein coupled receptor subunit encoded by the GABBR1 gene.

Function

GABA_B1 is a receptor for Gamma-aminobutyric acid. Upon binding, GABA_B1 will produce a slow and prolonged inhibitory effect. GABA_B1 is one part of a heterodimer, which is the GABA_B receptor, consisting of it and the related GABA_B2 protein. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants.^[1]

Interactions

GABBR1 has been shown to interact with ATF4^[2] and GABBR2.^[3]

See also

• GABAB receptor

References

Further reading

• Fraser DD, Mudrick-Donnon LA, MacVicar BA . Astrocytic GABA receptors. . Glia . 11 . 2 . 83–93 . 1994 . 7927650 . 10.1002/glia.440110203 . 8640162 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Kaupmann K, Huggel K, Heid J, Flor PJ, Bischoff S, Mickel SJ, McMaster G, Angst C, Bittiger H, Froestl W, Bettler B . Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors . Nature . 386 . 6622 . 239–46 . 1997 . 9069281 . 10.1038/386239a0 . 1997Natur.386..239K . 4345443 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Grifa A, Totaro A, Rommens JM, Carella M, Roetto A, Borgato L, Zelante L, Gasparini P . GABA (gamma-amino-butyric acid) neurotransmission: identification and fine mapping of the human GABAB receptor gene . Biochem. Biophys. Res. Commun. . 250 . 2 . 240–5 . 1998 . 9753614 . 10.1006/bbrc.1998.9296 .
• Goei VL, Choi J, Ahn J, Bowlus CL, Raha-Chowdhury R, Gruen JR . Human gamma-aminobutyric acid B receptor gene: complementary DNA cloning, expression, chromosomal location, and genomic organization . Biol. Psychiatry . 44 . 8 . 659–66 . 1999 . 9798068 . 10.1016/S0006-3223(98)00244-3 . 22947340 . free .
• Kaupmann K, Schuler V, Mosbacher J, Bischoff S, Bittiger H, Heid J, Froestl W, Leonhard S, Pfaff T, Karschin A, Bettler B . Human gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels . Proc. Natl. Acad. Sci. U.S.A. . 95 . 25 . 14991–6 . 1999 . 9844003 . 24563 . 10.1073/pnas.95.25.14991 . free .
• White JH, Wise A, Main MJ, Green A, Fraser NJ, Disney GH, Barnes AA, Emson P, Foord SM, Marshall FH . Heterodimerization is required for the formation of a functional GABA(B) receptor . Nature . 396 . 6712 . 679–82 . 1999 . 9872316 . 10.1038/25354 . 1998Natur.396..679W . 4406311 .
• Kuner R, Köhr G, Grünewald S, Eisenhardt G, Bach A, Kornau HC . Role of heteromer formation in GABAB receptor function . Science . 283 . 5398 . 74–7 . 1999 . 9872744 . 10.1126/science.283.5398.74 . 1999Sci...283...74K .
• Makoff A . Molecular cloning of human GABABR1 and its tissue distribution . Brain Res. Mol. Brain Res. . 64 . 1 . 137–40 . 1999 . 9889352 . 10.1016/S0169-328X(98)00316-7 .
• Peters HC, Kämmer G, Volz A, Kaupmann K, Ziegler A, Bettler B, Epplen JT, Sander T, Riess O . Mapping, genomic structure, and polymorphisms of the human GABABR1 receptor gene: evaluation of its involvement in idiopathic generalized epilepsy . Neurogenetics . 2 . 1 . 47–54 . 2000 . 9933300 . 10.1007/s100480050051 . 9649940 .
• Ng GY, Clark J, Coulombe N, Ethier N, Hebert TE, Sullivan R, Kargman S, Chateauneuf A, Tsukamoto N, McDonald T, Whiting P, Mezey E, Johnson MP, Liu Q, Kolakowski LF, Evans JF, Bonner TI, O'Neill GP . Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity . J. Biol. Chem. . 274 . 12 . 7607–10 . 1999 . 10075644 . 10.1074/jbc.274.12.7607 . free .
• Sander T, Peters C, Kämmer G, Samochowiec J, Zirra M, Mischke D, Ziegler A, Kaupmann K, Bettler B, Epplen JT, Riess O . Association analysis of exonic variants of the gene encoding the GABAB receptor and idiopathic generalized epilepsy . Am. J. Med. Genet. . 88 . 4 . 305–10 . 1999 . 10402495 . 10.1002/(SICI)1096-8628(19990820)88:4<305::AID-AJMG5>3.0.CO;2-X .
• Wise A, Green A, Main MJ, Wilson R, Fraser N, Marshall FH . Calcium sensing properties of the GABA(B) receptor . Neuropharmacology . 38 . 11 . 1647–56 . 1999 . 10587080 . 10.1016/S0028-3908(99)00119-7 . 19916703 .
• Sullivan R, Chateauneuf A, Coulombe N, Kolakowski LF, Johnson MP, Hebert TE, Ethier N, Belley M, Metters K, Abramovitz M, O'Neill GP, Ng GY . Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor . J. Pharmacol. Exp. Ther. . 293 . 2 . 460–7 . 2000 . 10773016 .
• Schwarz DA, Barry G, Eliasof SD, Petroski RE, Conlon PJ, Maki RA . Characterization of gamma-aminobutyric acid receptor GABAB(1e), a GABAB(1) splice variant encoding a truncated receptor . J. Biol. Chem. . 275 . 41 . 32174–81 . 2000 . 10906333 . 10.1074/jbc.M005333200 . free .
• White JH, McIllhinney RA, Wise A, Ciruela F, Chan WY, Emson PC, Billinton A, Marshall FH . The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx . Proc. Natl. Acad. Sci. U.S.A. . 97 . 25 . 13967–72 . 2001 . 11087824 . 17684 . 10.1073/pnas.240452197 . 2000PNAS...9713967W . free .
• Couve A, Kittler JT, Uren JM, Calver AR, Pangalos MN, Walsh FS, Moss SJ . Association of GABA(B) receptors and members of the 14-3-3 family of signaling proteins . Mol. Cell. Neurosci. . 17 . 2 . 317–28 . 2001 . 11178869 . 10.1006/mcne.2000.0938 . 24344705 .
• Muñoz A, Arellano JI, DeFelipe J . GABABR1 receptor protein expression in human mesial temporal cortex: changes in temporal lobe epilepsy . J. Comp. Neurol. . 449 . 2 . 166–79 . 2002 . 12115687 . 10.1002/cne.10287 . 21596884 .

External links

• Web site: GABA_B Receptors: GABA_B1 . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . 2008-12-04 . 2016-03-03 . https://web.archive.org/web/20160303170056/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2197 . dead .

Notes and References

1. Web site: Entrez Gene: GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1.
2. . The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx . . 97 . 25 . 13967–72 . December 2000 . 11087824 . 17684 . 10.1073/pnas.240452197 . 2000PNAS...9713967W . free .
3. . Heterodimerization is required for the formation of a functional GABA(B) receptor . . 396 . 6712 . 679–82 . December 1998 . 9872316 . 10.1038/25354 . 1998Natur.396..679W . 4406311 .