Grb2 associated binding protein 3 explained

GRB2 associated binding protein 3 is a protein that in humans is encoded by the GAB3 gene.^[1]

Function

This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Alternative splicing results in multiple transcript variants.

Further reading

• Bourgin C, Bourette RP, Arnaud S, Liu Y, Rohrschneider LR, Mouchiroud G . Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation . Mol. Cell. Biol. . 22 . 11 . 3744–56 . 2002 . 11997510 . 133813 . 10.1128/mcb.22.11.3744-3756.2002.
• Sliz. Anna. Locker. Kathryn C. S.. Lampe. Kristin. Godarova. Alzbeta. Plas. David R.. Janssen. Edith M.. Jones. Helen. Herr. Andrew B.. Hoebe. Kasper. Gab3 is required for IL-2– and IL-15–induced NK cell expansion and limits trophoblast invasion during pregnancy. Science Immunology. 4. 38. 2019. eaav3866. 2470-9468. 10.1126/sciimmunol.aav3866. 31375526. 7068803.

Notes and References

1. Web site: GAB3 GRB2 associated binding protein 3 [Homo sapiens (human) ]]. National Center for Biotechnology Information. 2019-08-03.