| Country: | CHN |
| Type: | Expwy |
| Route: | 80 |
| Alternate Name: | Guangkun Expressway 广昆高速公路 |
| Length Km: | 1511 |
| Length Notes: | Length when complete. |
| Map: | G80 map.svg |
| Length Ref: | [1] |
| Direction A: | East |
| Terminus A: | G1508 Guangzhou Ring Expressway, Guangzhou, Guangdong |
| Direction B: | West |
| Terminus B: | Shihuguan Interchange, 2nd Ring Road, Kunming, Yunnan |
| Previous Type: | Expwy |
| Previous Route: | 78 |
| Previous Dab: | Shantou–Kunming Expressway |
| Next Type: | Expwy |
| Next Route: | 8011 |
| Next Dab: | Kaiyuan–Hekou Expressway |
The Guangzhou–Kunming Expressway, designated as G80 and commonly referred to as the Guangkun Expressway is an expressway in China that connects the cities of Guangzhou, Guangdong, and Kunming, Yunnan. When complete, it will be 1511km (939miles) in length.
The section of roadway from Suolongshi, Mile County, Honghe Hani and Yi Autonomous Prefecture, Yunnan to Shilin Yi Autonomous County still follows China National Highway 326 which is not a grade-separated expressway. It is currently being upgraded to expressway standards.