| Country: | CHN |
| Type: | Expwy |
| Route: | 0425 |
| Spur Type: | Expwy |
| Spur Of: | 4 |
| Alternate Name: | Guang'ao Expressway 广澳高速公路 |
| Length Km: | 153 |
| Length Ref: | [1] |
| Map: | Guangdong G4w.svg |
| Map Notes: | Guangzhou - Macau Expressway in red. |
| Photo Notes: | The expressway approaching the S105 Nansha Port Expressway |
| Direction A: | North |
| Terminus A: | in Guangzhou, Guangdong |
| Direction B: | South |
| Terminus B: | Macau (when complete) in Zhuhai, Guangdong (current) |
| Previous Type: | Expwy |
| Previous Route: | 0424 |
| Next Type: | Expwy |
| Next Route: | 5 |
The Guangzhou–Macau Expressway, designated as G0425 and commonly referred to as the Guang'ao Expressway, is an expressway that connects the cities of Guangzhou, Guangdong, and Macau, a Special Administrative Region of the People's Republic of China. It is a spur line of the G4 Beijing–Hong Kong and Macau Expressway.
The extension to Macau at the Lotus Bridge is planned, so the current southern terminus is in Zhuhai at Zhuhai Avenue.
The major cities connected by this expressway are: