| Country: | CHN |
| Type: | Expwy |
| Route: | 4221 |
| Map: | G4221 map.svg |
| Direction A: | North |
| Direction B: | South |
| Previous Type: | Expwy |
| Previous Route: | 4219 |
| Next Type: | Expwy |
| Next Route: | 4222 |
G4221 Shanghai–Wuhan Expressway is an expressway in China. It starts at Shanghai, passing through Taicang, Changshu, Jiangyin, Jintan District of Changzhou, Lishui District of Nanjing, Ma'anshan, Chao Lake, Lujiang County, Yuexi County, Yingshan County and Tuanfeng County, ending in Wuhan.[1] [2]