| Country: | CHN |
| Type: | Expwy |
| Route: | 0422 |
| Alternate Name: | Wushen Expressway 武深高速公路 |
| Direction A: | North |
| Terminus A: | Wuhan, Hubei |
| Direction B: | South |
| Terminus B: | Shenzhen, Guangdong |
| Previous Type: | Expwy |
| Previous Route: | 0421 |
| Previous Dab: | Xuchang–Guangzhou Expressway |
| Next Type: | Expwy |
| Next Route: | 0423 |
| Next Dab: | Lechang–Guangzhou Expressway |
The Wuhan - Shenzhen Expressway, officially designated as G0422 and commonly abbreviated as Wushen Expressway, serves as a vital expressway in Central South China, seamlessly connecting the bustling cities of Wuhan, Hubei and Shenzhen, Guangdong.