| Type: | commune |
| County: | Mehedinți |
| Gârla Mare | |
| Leader Name: | Dumitru Baicu |
| Leader Party: | PSD |
| Leader Term: | 2020 - 2024 |
| Coordinates: | 44.2167°N 68°W |
| Elevation: | 61 |
| Area Total: | 62.56 |
| Population Total: | auto |
| Postal Code: | 227210 |
Gârla Mare is a commune located in Mehedinți County, Oltenia, Romania. It is composed of a single village, Gârla Mare. It also included Vrata village until 2004, when it was split off to form Vrata Commune.
During the Communist era, this commune was an important cultural and economic centre. It was directly connected to the Danube trade routes through its port. Efficient use of the relief and local resources allowed for the development of farms and crops that would then be redistributed among neighboring towns. After the fall of communism in 1989, a great deal of resources have been lost as a consequence of poor maintenance and depreciation.