Fudosteine Explained

Tradename:	Cleanal
Legal Status:	Rx in Japan
Synonyms:	S-(3-Hydroxypropyl)-L-cysteine
Cas Number:	13189-98-5
Chebi:	31637
Chembl:	1555183
Chemspiderid:	118692
Pubchem:	134669
Unii:	UR9VPI71PT
Kegg:	D01845
Iupac Name:	(2R)-2-Amino-3-(3-hydroxypropylsulfanyl)propanoic acid
C:	6
H:	13
N:	1
O:	3
S:	1
Stdinchi:	1S/C6H13NO3S/c7-5(6(9)10)4-11-3-1-2-8/h5,8H,1-4,7H2,(H,9,10)/t5-/m0/s1
Stdinchikey:	KINWYTAUPKOPCQ-YFKPBYRVSA-N
Smiles:	C(CO)CSC[C@@H](C(=O)O)N

Fudosteine (Cleanal) is a mucolytic agent.^[1] In Japan, it is approved for the treatment of bronchial asthma, chronic bronchitis, pulmonary emphysema, bronchiectasis, pulmonary tuberculosis, pneumoconiosis, atypical mycobacterial disease, and diffuse panbronchiolitis.^[2]

Fudosteine works by increasing mucin secretion by inhibiting expression of the protein mucin 5AC.^[3]

Notes and References

1. Rhee CK, Kang CM, You MB, Yoon HK, Kim YK, Kim KH, Moon HS, Park SH, Song JS . Effect of fudosteine on mucin production . The European Respiratory Journal . 32 . 5 . 1195–1202 . November 2008 . 18579549 . 10.1183/09031936.00018508 .
2. Web site: Fudosteine . Inxight Drugs . National Center for Advancing Translational Sciences (NCATS), U.S. National Institutes of Health .
3. Antonela Antoniu S . Fudosteine effects on mucin production . Expert Opinion on Investigational Drugs . 18 . 1 . 105–107 . January 2009 . 19053887 . 10.1517/13543780802623863 . 219294005 .