Frizzled-2 Explained

Frizzled-2 (Fz-2) is a protein that in humans is encoded by the FZD2 gene.^{[1] [2] [3]}

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The expression of the FZD2 gene appears to be developmentally regulated, with high levels of expression in fetal kidney and lung and in adult colon and ovary.^[3]

Further reading

• Wang Y, Macke JP, Abella BS . A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. . J. Biol. Chem. . 271 . 8 . 4468–76 . 1996 . 8626800 . 10.1074/jbc.271.8.4468 . etal. free .
• Finch PW, He X, Kelley MJ . Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. . Proc. Natl. Acad. Sci. U.S.A. . 94 . 13 . 6770–5 . 1997 . 9192640 . 10.1073/pnas.94.13.6770 . 21233 . 1997PNAS...94.6770F . etal. free .
• Tanaka S, Akiyoshi T, Mori M . A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. . Proc. Natl. Acad. Sci. U.S.A. . 95 . 17 . 10164–9 . 1998 . 9707618 . 10.1073/pnas.95.17.10164 . 21479 . 1998PNAS...9510164T . etal. free .
• Hering H, Sheng M . Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95. . FEBS Lett. . 521 . 1–3 . 185–9 . 2002 . 12067714 . 10.1016/S0014-5793(02)02831-4 . 39243103 . free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Oishi I, Suzuki H, Onishi N . The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway . Genes Cells . 8 . 7 . 645–54 . 2004 . 12839624 . 10.1046/j.1365-2443.2003.00662.x . 40902391 . etal. free .
• Omoto S, Hayashi T, Kitahara K . Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R) . Ophthalmic Genet. . 25 . 2 . 81–90 . 2004 . 15370539 . 10.1080/13816810490514270 . 32817238 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.

External links

• Web site: Frizzled Receptors: FZD₂ . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . 2008-12-04 . 2016-03-03 . https://web.archive.org/web/20160303204756/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3060 . dead .

Notes and References

1. Zhao Z, Lee CC, Baldini A, Caskey CT . A human homologue of the Drosophila polarity gene frizzled has been identified and mapped to 17q21.1 . Genomics . 27 . 2 . 370–3 . Nov 1995 . 7558010 . 10.1006/geno.1995.1060 .
2. Sagara N, Toda G, Hirai M, Terada M, Katoh M . Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7 . Biochem Biophys Res Commun . 252 . 1 . 117–22 . Dec 1998 . 9813155 . 10.1006/bbrc.1998.9607 .
3. Web site: Entrez Gene: FZD2 frizzled homolog 2 (Drosophila).