Frizzled-10 Explained
Frizzled-10 (Fz-10) is a protein that in humans is encoded by the FZD10 gene.[1] [2] Fz-10 has also been designated as CD350 (cluster of differentiation 350).
Function
This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer.
Further reading
- Finch PW, He X, Kelley MJ, Uren A, Schaudies RP, Popescu NC, Rudikoff S, Aaronson SA, Varmus HE, Rubin JS . Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action . Proceedings of the National Academy of Sciences of the United States of America . 94 . 13 . 6770–5 . Jun 1997 . 9192640 . 21233 . 10.1073/pnas.94.13.6770 . 1997PNAS...94.6770F . free .
- Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K . A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals . Proceedings of the National Academy of Sciences of the United States of America . 95 . 17 . 10164–9 . Aug 1998 . 9707618 . 21479 . 10.1073/pnas.95.17.10164 . 1998PNAS...9510164T . free .
- Kumar S, Connor JR, Dodds RA, Halsey W, Van Horn M, Mao J, Sathe G, Mui P, Agarwal P, Badger AM, Lee JC, Gowen M, Lark MW . Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries . Osteoarthritis and Cartilage . 9 . 7 . 641–53 . Oct 2001 . 11597177 . 10.1053/joca.2001.0421 . free .
- Terasaki H, Saitoh T, Shiokawa K, Katoh M . Frizzled-10, up-regulated in primary colorectal cancer, is a positive regulator of the WNT - beta-catenin - TCF signaling pathway . International Journal of Molecular Medicine . 9 . 2 . 107–12 . Feb 2002 . 11786918 . 10.3892/ijmm.9.2.107 .
- Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y . Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R) . Ophthalmic Genetics . 25 . 2 . 81–90 . Jun 2004 . 15370539 . 10.1080/13816810490514270 . 32817238 .
External links
- Web site: Frizzled Receptors: FZD10 . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . 2008-12-04 . 2016-03-03 . https://web.archive.org/web/20160303202556/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3068 . dead .
Notes and References
- Koike J, Takagi A, Miwa T, Hirai M, Terada M, Katoh M . Molecular cloning of Frizzled-10, a novel member of the Frizzled gene family . Biochemical and Biophysical Research Communications . 262 . 1 . 39–43 . Aug 1999 . 10448064 . 10.1006/bbrc.1999.1161 .
- Web site: Entrez Gene: FZD10 frizzled homolog 10 (Drosophila).
