Friedrich Sigmund Merkel Explained

Friedrich Sigmund Merkel (5 April 1845  - 28 May 1919) was a leading German anatomist and histopathologist of the late 19th century. In 1875, he provided the first full description of Tastzellen (touch cells), which occur in the skin of all vertebrates.^[1] They were subsequently given the eponym "Merkel cells" in 1878 by Robert Bonnet (1851–1921).

Merkel was a native of Nürnberg. In 1869 he earned his medical doctorate from the University of Erlangen, becoming habilitated in the field of anatomy during the following year. He was a professor at the Universities of Rostock (from 1872), Königsberg (from 1883) and Göttingen (from 1885). At Göttingen, he worked under Jacob Henle and married Henle's daughter Anne. He published a multivolume textbook on human anatomy and originated the color scheme used by most anatomy texts today: red for arteries, blue for veins, and yellow for nerves.^[2] He introduced xylene as a clearing agent in histology, and it is still used today^[3] Two of his better known assistants were Dietrich Barfurth (1849-1927) and Hermann Kuhnt (1850-1925).

The term "Merkel's spur" is synonymous with the femoral calcar.^[4]

Selected publications

• Makroskopische Anatomie des Auges und seiner Umgebungen; In Handbuch der Augenheilkunde; Leipzig, 1874; second edition with Erich Kallius (1867-1935) in 1901 - Macroscopic anatomy of the eye and its environment.
• Das Mikroskop und seine Anwendung, 1875 - The microscope and its application.
• Über die Endigungen der sensiblen Nerven in der Haut der Wirbeltiere, Rostock, 1880 - On sensory nerve terminations in the skin of vertebrates.
• Handbuch der topographischen Anatomie 1885 to 1907 - Manual of topographical anatomy.
• Ergebnisse der Anatomie und Entwickelungsgeschichte; from 1892, one annual volume, published with Robert Bonnet (1851-1921) - Anatomical results and developmental history.
• Menschliche Embryonen verschiedenen Alters auf Medianschnitten untersucht, 1894.
• Die Anatomie des Menschen. Mit Hinweisen auf die ärztliche Praxis, (11 volumes) 1913 to 1918 - Human anatomy, with reference to the practice of medicine.^[5]

External links

• Friedrich Sigmund Merkel @ Who Named It

Notes and References

1. Merkel FS. (1875). Tastzellen und Tastkörperchen bei den Hausthieren und beim Menschen. Archiv für mikroskopische Anatomie, 11: 636-652.
2. Demystifying Merkel. JAMA Dermatol. . August 2014. Robert Denison Griffith . Mohammad-Ali Yazdani Abyaneh . Leyre Falto-Aizpurua . Keyvan Nouri. 150. 8 . 814 . 10.1001/jamadermatol.2014.225. 25133439.
3. http://www.deutsche-biographie.de/sfz61978.html Neue Deutsche Biographie (NDB). Band 17
4. http://www.whonamedit.com/synd.cfm/3825.html Merkel's spur
5. http://www.whonamedit.com/person_bibliography/3134/ Friedrich Sigmund Merkel - bibliography