Friedhelm Hildebrandt Explained

Friedhelm Hildebrandt (born February 11, 1957) is the William E. Harmon Professor of Pediatrics at Harvard Medical School and Chief of the Division of Nephrology at Boston Children's Hospital.[1] He was formerly an Investigator of the Howard Hughes Medical Institute (HHMI) and the Frederick G.L. Huetwell Professor of Pediatrics at the University of Michigan.[2] [3]

Early life and education

Hildebrandt received his M.D. degree from Heidelberg University (Germany), obtained his pediatrics and nephrology subspecialty training at Marburg University Children's Hospital, and was a postdoctoral research fellow in nephrology at Yale School of Medicine (Peter Aronson & Peter Igarashi).

Research

Friedhelm Hildebrandt identified and functionally characterized multiple kidney diseases caused by single-genes (Mendelian) including nephrotic syndrome, cystic renal ciliopathies,[4] and congenital anomalies of the kidney [5]

Hildebrandt was elected to the American National Academy of Medicine in 2015,[6] Leopoldina in 2007,[7] and to the Association of American Physicians in 2005.[8] He is a recipient of the Homer Smith Award of the American Society of Nephrology (2014),[9] the Alfred R. Newton Award of the International Society of Nephrology (ISN) (2017),[10] and the E. Mead Johnson Award[11] from the Society for Pediatric Research (2004).

Hildebrandt’s group has identified over 80 novel causative genes of the 240 genes that are currently known to cause chronic kidney disease, if mutated. His laboratory delineated the related disease mechanisms by generating animal models of human kidney disease in mice, zebrafish, C. elegans, and Drosophila as well in cell-based systems. He demonstrated that in a very high percentage of cases with early-onset chronic kidney disease a single-gene cause may be identified.[12] [13] Link to pertinent publications.

Notes and References

  1. Web site: BCH Division of Nephrology . BCH Division of Nephrology Hildebrandt . 29 March 2020.
  2. Web site: HHMI . HHMI - Hildebrandt . HHMI . 29 March 2020.
  3. Web site: UoM . UoM Hildebrandt . University of Michigan . 29 March 2020.
  4. Hildebrandt . F . Benzing . T . Katsanis . N . Ciliopathies. . The New England Journal of Medicine . 21 April 2011 . 364 . 16 . 1533–43 . 10.1056/NEJMra1010172 . 21506742 . 3640822 .
  5. Vivante . A . Hildebrandt . F . Exploring the genetic basis of early-onset chronic kidney disease. . Nature Reviews. Nephrology . March 2016 . 12 . 3 . 133–46 . 10.1038/nrneph.2015.205 . 26750453. 5202482 .
  6. Web site: National Academy of Medicine . National Academy of Medicine - Hildebrandt . 29 March 2020.
  7. Web site: Leopoldina . Leopoldina - Hildebrandt . 29 March 2020.
  8. Web site: Association of American Physicians . 29 March 2020 . Association of American Physicians . AAP.
  9. Web site: ASN - Homer Smith Award . Homer Smoth W. Award . American Society of Nephrology . 29 March 2020.
  10. Web site: ISN Awards . A.N. Richards Award . International Society of Nephrology . 29 March 2020.
  11. Web site: Past Award Recipients . E. Mead Johnson Award . Society for Pediatric Research . 29 March 2020.
  12. Sadowski . Carolin E. . Lovric . Svjetlana . Ashraf . Shazia . Pabst . Werner L. . Gee . Heon Yung . Kohl . Stefan . Engelmann . Susanne . Vega-Warner . Virginia . Fang . Humphrey . Halbritter . Jan . Somers . Michael J. . Tan . Weizhen . Shril . Shirlee . Fessi . Inès . Lifton . Richard P. . Bockenhauer . Detlef . El-Desoky . Sherif . Kari . Jameela A. . Zenker . Martin . Kemper . Markus J. . Mueller . Dominik . Fathy . Hanan M. . Soliman . Neveen A. . Hildebrandt . Friedhelm . A Single-Gene Cause in 29.5% of Cases of Steroid-Resistant Nephrotic Syndrome . Journal of the American Society of Nephrology . June 2015 . 26 . 6 . 1279–1289 . 10.1681/ASN.2014050489 . 25349199 . 4446877 .
  13. Braun . Daniela A. . Schueler . Markus . Halbritter . Jan . Gee . Heon Yung . Porath . Jonathan D. . Lawson . Jennifer A. . Airik . Rannar . Shril . Shirlee . Allen . Susan J. . Stein . Deborah . Al Kindy . Adila . Beck . Bodo B. . Cengiz . Nurcan . Moorani . Khemchand N. . Ozaltin . Fatih . Hashmi . Seema . Sayer . John A. . Bockenhauer . Detlef . Soliman . Neveen A. . Otto . Edgar A. . Lifton . Richard P. . Hildebrandt . Friedhelm . Whole exome sequencing identifies causative mutations in the majority of consanguineous or familial cases with childhood-onset increased renal echogenicity . Kidney International . February 2016 . 89 . 2 . 468–475 . 10.1038/ki.2015.317 . 26489029 . 4840095 .

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