| Competition: | Division 1 |
| Dates: | 24 July 1980 – 2 June 1981 |
| Season: | 1980–81 |
| Winners: | Saint-Étienne (10th title) |
| Relegated: | Nîmes Angers |
| Continentalcup1: | European Cup |
| Continentalcup1 Qualifiers: | Saint-Étienne |
| Continentalcup2: | UEFA Cup |
| Continentalcup2 Qualifiers: | Nantes Bordeaux Monaco |
| Continentalcup3: | Cup Winners' Cup |
| Continentalcup3 Qualifiers: | Bastia |
| League Topscorer: | Delio Onnis (24 goals) |
| Matches: | 380 |
| Total Goals: | 1064 |
| Prevseason: | 1979–80 |
| Nextseason: | 1981–82 |
1980–81 Division 1 was the 43rd season of the French top association football league, played from July 1980 to June 1981. The league was won by AS Saint-Etienne with 57 points, for whom this was their 10th title.
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