| Season: | 1945–46 |
| Winners: | Lille 1st title |
| League Topscorer: | René Bihel (28) |
| Matches: | 306 |
| Total Goals: | 1080 |
| Nextseason: | 1946–47 |
Lille OSC won Division 1 season 1945/1946, the first professional football season since the end of World War II, of the French Association Football League with 45 points.
Club from Alsace-Loraine, annexed by Nazi Germany during WW2, could not be relegated.
Promoted from Division 2, who will play in Division 1 season 1946/1947
| Rank | Player | Club | Goals |
|---|---|---|---|
| 1 |  René Bihel | Lille | 28 |
| 2 | Pierre Sinibaldi | Reims | 26 |
| 3 | Antoine Rodriguez | Saint-Étienne | 22 |
| 4 | Louis de Sainte de Maréville | Marseille | 21 |
| 5 |  Désiré Koranyi | Sète | 20 |
| 6 | Jean Baratte | Lille | 19 |
| 7 | René Alpsteg | Saint-Étienne | 18 |
 Stefan Dembicki | Lens | ||
| René Lozia | Red Star | ||
| Joseph Rabstejnek | Rennes |