This is a list of the 100 best-selling singles in France during the 2000s (i.e. release in France from January 1, 2000 to December 31, 2009).[1]
| Pos. | Artist | Single | Year | Country | Sales | Peak | |||||||
| 1 | Las Ketchup | "The Ketchup Song (Aserejé)" | 2002 | Spain | 1,750,000 | 1 | |||||||
| 2 | Ilona Mitrecey | "Un Monde parfait" | 2005 | France | 1,520,000 | 1 | |||||||
| 3 | Yannick | "Ces soirées-là" | 2000 | France | 1,512,000 | 1 | |||||||
| 4 | Star Academy 1 | "La Musique (Angelica)" | 2001 | France | 1,425,000 | 1 | |||||||
| 5 | Damien Sargue, Philippe D'Avilla and Grégori Baquet | "Les Rois du monde" | 2000 | France | 1,410,000 | 1 | |||||||
| 6 | Alizée | "Moi... Lolita" | 2000 | France | 1,282,000 | 2 | |||||||
| 7 | Bratisla Boys | "Stach Stach" | 2002 | France | 1,250,000 | 1 | |||||||
| 8 | Crazy Frog | "Axel F" | 2005 | Sweden | 1,236,100 | 1 | |||||||
| 9 | Daniel Lévi | "L'Envie d'aimer" | 2000 | France | 1,200,000 | 2 | |||||||
| 10 | L5 | "Toutes les femmes de ta vie" | 2001 | France | 1,165,000 | 1 | |||||||
| 11 | O-Zone | "Dragostea din tei" | 2004 | Romania | 1,101,000 | 1 | |||||||
| 12 | DJ BoBo | "Chihuahua" | 2003 | Switzerland | 1,050,000 | 1 | |||||||
| 13 | Johnny Hallyday | "Marie" | 2002 | France | 1,045,000 | 1 | |||||||
| 14 | Daddy DJ | "Daddy DJ" | 2000 | France | 999,000 | 2 | |||||||
| 15 | Garou | "Seul" | 2000 | Canada | 990,000 | 1 | |||||||
| 16 | Shakira | "Whenever, Wherever" | 2002 | Colombia | 970,000 | 1 | |||||||
| 17 | Kylie Minogue | "Can't Get You Out of My Head" | 2001 | Australia | 918,000 | 1 | |||||||
| 18 | Les Lofteurs | "Up & Down" | 2001 | France | 863,000 | 1 | |||||||
| 19 | Geri Halliwell | "It's Raining Men" | 2001 | United Kingdom | 812,000 | 1 | |||||||
| 20 | Indochine | "J'ai demandé à la lune" | 2001 | France | 780,000 | 1 | |||||||
| 21 | Cécilia Cara and Damien Sargue | "Aimer" | 2000 | France | 777,000 | 2 | |||||||
| 22 | Garou and Celine Dion | "Sous le vent" | 2001 | Canada | 744,000 | 1 | |||||||
| 23 | Tragédie | "Hey Oh" | 2003 | France | 656,000 | 1 | |||||||
| 24 | Natasha St-Pier | "Tu trouveras" | 2002 | Canada | 652,000 | 3 | |||||||
| 25 | Lorie | "Près de moi" | 2001 | France | 634,000 | 2 | |||||||
| 26 | Umberto Tozzi and Lena K | "Ti amo (Rien que des mots)" | 2002 | Italy France | 609,000 | 3 | |||||||
| 27 | Rohff | "Qui est l'exemple ?" | 2002 | France | 599,000 | 1 | |||||||
| 28 | Alizée | "L'Alizé" | 2000 | France | 582,000 | 1 | |||||||
| 29 | Anastacia | "I'm Outta Love" | 2000 | United States | 573,000 | 2 | |||||||
| 30 | Saïan Supa Crew | "Angela" | 2000 | France | 568,000 | 2 | |||||||
| 31 | Aventura | "Obsesión" | 2004 | United States | 565,000 | 1 | |||||||
| 32 | Amel Bent | "Ma philosophie" | 2005 | France | 560,000 | 1 | |||||||
| 33 | Hélène Ségara | "Elle, tu l'aimes..." | 2000 | France | 545,000 | 3 | |||||||
| 34 | Mylène Farmer and Seal | "Les Mots" | 2001 | France United Kingdom | 539,000 | 2 | |||||||
| 35 | Santana and The Product G&B | "Maria Maria" | 2000 | United States | 535,000 | 1 | |||||||
| 36 | Chimène Badi | "Entre nous" | 2003 | France | 531,000 | 1 | |||||||
| 37 | KCPK | "We Will Rock You (Remix)" | 2003 | France | 530,000 | 2 | |||||||
| 38 | Marc Lavoine and Cristina Marocco | "J'ai tout oublié" | 2001 | France Italy | 526,000 | 1 | |||||||
| 39 | Star Academy 2 | "Paris Latino" | 2002 | France | 526,000 | 1 | |||||||
| 40 | Renaud and Axelle Red | "Manhattan-Kaboul" | 2002 | France Belgium | 523,000 | 2 | |||||||
| 41 | Hermes House Band featuring DJ Ötzi | "Live Is Life" | 2002 | Netherlands Austria | 518,000 | 2 | |||||||
| 42 | Lorie | "Sur un air latino" | 2003 | France | 517,000 | 1 | |||||||
| 43 | Alphonse Brown | "Le Frunkp" | 2003 | France | 508,000 | 1 | |||||||
| 44 | Assia | "Elle est à toi" | 2000 | Algeria | 508,000 | 3 | |||||||
| 45 | Diam's | "DJ" | 2003 | Cyprus | 508,000 | 2 | |||||||
| 46 | Jocelyne Labylle and Cheela featuring Passi and Jacob Desvarieux | "Laisse parler les gens" | 2003 | Guadeloupe Republic of the Congo France | 507,000 | 1 | |||||||
| 47 | R. Kelly | "If I Could Turn Back the Hands of Time" | 2002 | United States | 505,000 | 2 | |||||||
| 48 | Ève Angeli | "Avant de partir" | 2000 | France | 501,000 | 4 | |||||||
| 49 | MC Solaar | "Inch'Allah" | 2002 | France | 500,000 | 1 | |||||||
| 50 | Florent Pagny | "Ma liberté de penser" | 2003 | France | 497,000 | 1 | |||||||
| 51 | Star Academy 4 | "Laissez-moi danser" | 2004 | France | 495,000 | 1 | |||||||
| 52 | Pinocchio | "T'es pas cap Pinocchio" | 2005 | France | 483,300 | 2 | |||||||
| 53 | K.Maro | "Femme Like U (Donne-moi ton corps)" | 2004 | Lebanon | 482,000 | 1 | |||||||
| 54 | Crazy Frog | "Popcorn" | 2005 | Sweden | 480,100 | 1 | |||||||
| 55 | Eminem | "Without Me" | 2002 | United States | 478,000 | 3 | |||||||
| 56 | Jenifer | "Au soleil" | 2002 | France | 475,000 | 2 | |||||||
| 57 | Modjo | "Lady (Hear Me Tonight)" | 2000 | France | 474,000 | 7 | |||||||
| 58 | Bonnie Tyler and Kareen Antonn | "Si demain... (Turn Around)" | 2003 | United Kingdom France | 473,000 | 1 | |||||||
| 59 | Isabelle Boulay | "Parle-moi" | 2000 | Canada | 468,000 | 2 | |||||||
| 60 | MC Solaar | "Hasta la Vista" | 2001 | France | 466,000 | 1 | |||||||
| 61 | Fatal Bazooka | "Fous ta cagoule" | 2006 | France | 463,900 | 1 | |||||||
| 62 | Dezil' | "San ou (la rivière)" | 2005 | Seychelles | 463,600 | 2 | |||||||
| 63 | Johnny Hallyday | "Tous ensemble" | 2002 | France | 461,000 | 1 | |||||||
| 64 | Shaggy featuring Ricardo "RikRok" Ducent | "It Wasn't Me" | 2001 | Jamaica United Kingdom | 458,000 | 1 | |||||||
| 65 | Star Academy 3 | "L'Orange / Wot" | 2003 | France | 449,000 | 1 | |||||||
| 66 | Ilona Mitrecey | "C'est les vacances" | 2005 | France | 445,100 | 2 | |||||||
| 67 | Phil Barney and Marlène Duval | "Un enfant de toi" | 2002 | France | 439,000 | 1 | |||||||
| 68 | Zazie and Axel Bauer | "À ma place" | 2001 | France | 432,000 | 4 | |||||||
| 69 | Garou and Michel Sardou | "La Rivière de notre enfance" | 2004 | Canada France | 425,000 | 1 | |||||||
| 70 | Mary J. Blige | "Family Affair" | 2001 | United States | 420,000 | 1 | |||||||
| 71 | Star Academy 3 | "La Bamba" | 2003 | France | 417,000 | 2 | |||||||
| 72 | Billy Crawford | "Trackin'" | 2001 | Philippines United States | 416,000 | 5 | |||||||
| 73 | Nuttea | "Elle te rend dingue (poom poom short)" | 2000 | France | 410,000 | 4 | |||||||
| 74 | Madonna | "Hung Up" | 2005 | United States | 409,100 | 1 | |||||||
| 75 | Yannick Noah | "La voix des sages (No More Fighting)" | 2001 | France | 408,000 | 3 | |||||||
| 76 | T-Rio | "(Choopeta) Mamãe eu quero" | 2004 | Brazil | 408,000 | 2 | |||||||
| 77 | Nuttea | "Trop peu de temps" | 2001 | France | 407,000 | 5 | |||||||
| 78 | King Africa | "La Bomba" | 2000 | Argentina | 406,000 | 4 | |||||||
| 79 | Manu Chao | "Me Gustas Tú" | 2001 | France | 401,000 | 2 | |||||||
| 80 | Les G.O. Cul-ture | "Darla dirladada" | 2000 | France | 398,000 | 1 | |||||||
| 82 | Eminem | "Stan" | 2000 | United States | 398,000 | 4 | |||||||
| 83 | Papi Sánchez | "Enamorame" | 2003 | Dominican Republic | 396,000 | 2 | |||||||
| 84 | Supermen Lovers | "Starlight" | 2001 | France | 393,000 | 2 | |||||||
| 85 | The Black Eyed Peas | "I Gotta Feeling" | 2009 | United States | 390,000 | 2 | |||||||
| 86 | Eminem | "The Real Slim Shady" | 2000 | United States | 382,000 | 6 | |||||||
| 87 | Mad'House | "Like a Prayer" | 2002 | Netherlands | 379,000 | 5 | |||||||
| 88 | Faf Larage | "Pas le temps" | 2002 | France | 378,000 | 1 | |||||||
| 89 | David Guetta featuring Chris Willis | "Love Don't Let Me Go" | 2002 | France United States | 376,000 | 4 | |||||||
| 90 | Calogero and Passi | "Face à la mer" | 2004 | France Republic of the Congo | 370,000 | 3 | |||||||
| 91 | Leslie featuring Amine | "Sobri (notre destin)" | 2004 | France Morocco | 365,000 | 2 | |||||||
| 92 | Lorna | "Papi chulo... (te traigo el mmmm...)" | 2003 | Panama | 362,000 | 1 | |||||||
| 93 | Dante Thomas featuring Pras | "Miss California" | 2001 | United States | 353,000 | 3 | |||||||
| 94 | Kamini | "Marly-Gomont" | 2006 | France | 351,000 | 1 | |||||||
| 95 | The Spooks | "Things I've Seen" | 2000 | United States | 351,000 | 4 | |||||||
| 96 | Da Muttz | "Wassuup!" | 2001 | United Kingdom | 350,000 | 2 | |||||||
| 97 | Sully Sefil | "J'voulais" | 2001 | France | 350,000 | 2 | |||||||
| 98 | Sinsemilia | "Tout le bonheur du Monde" | 2004 | France | 350,000 | 4 | |||||||
| 99 | Helmut Fritz | "Ça m'énerve" | 2009 | France | 348,020 | 1 | |||||||
| 100 | La Plage | "Coup de Boule" | 2006 | France | 343,000 | 1 | |||||||