| Frederick Walter DeStefano | |
| Birth Date: | 4 April 1900 |
| Birth Place: | Coal City, Illinois, U.S. |
| Death Date: | (aged 74) |
| Death Place: | Houston, Texas, U.S. |
| Stats: | y |
| Playing Years1: | 1924–1925 |
Fred DeStefano (April 4, 1900 – June 27, 1974) was a professional American football player who played running back for two seasons for the Chicago Cardinals.[1] After retiring from football, he became a physician, and died in Houston, Texas in 1974 of multiple organ failure.[2]