| Fred Applegate | |
| Position: | Pitcher |
| Bats: | Left |
| Throws: | Left |
| Birth Date: | May 9, 1879 |
| Birth Place: | Williamsport, Pennsylvania |
| Death Place: | Williamsport, Pennsylvania |
| Debutleague: | MLB |
| Debutdate: | September 30 |
| Debutyear: | 1904 |
| Debutteam: | Philadelphia Athletics |
| Finalleague: | MLB |
| Finaldate: | October 10 |
| Finalyear: | 1904 |
| Finalteam: | Philadelphia Athletics |
| Statleague: | MLB |
| Stat1label: | Win–loss record |
| Stat1value: | 1–2 |
| Stat3label: | Strikeouts |
| Stat3value: | 12 |
| Stat2label: | Earned run average |
| Stat2value: | 6.43 |
| Teams: | |
Frederick Romaine Applegate (May 9, 1879 – April 21, 1968) was a Major League Baseball pitcher in 1904 for the Philadelphia Athletics. Between September 30 and October 10, he started and completed three games, winning 1 and losing 2 with an ERA of 6.43. His lone major league win came against the Washington Senators in his third and final start. The score was 7–6.
A good hitter and fielder during his brief time in the big leagues, he batted .286 (2-for-7) and handled eight chances without making an error.
A native of Williamsport, Pennsylvania, he died in his hometown at the age of 88.