| Fray Mamerto Esquiú | |
| Native Name: | Departamento Fray Mamerto Esquiú |
| Settlement Type: | Department |
| Coordinates: | -28.3833°N -107°W |
| Subdivision Type: | Country |
| Subdivision Name: | Argentina |
| Established Title: | Established |
| Established Date: | ? |
| Founder: | ? |
| Seat Type: | Seat |
| Seat: | San José |
| Leader Title: | Mayor |
| Leader Name: | Humberto F. Valdez, FCS |
| Unit Pref: | Metric |
| Area Total Km2: | 280 |
| Population Total: | 10,658 |
| Population Density Km2: | auto |
| Population Demonym: | ? |
| Postal Code Type: | Postal Code |
| Postal Code: | ? |
| Postal2 Code Type: | IFAM |
| Postal2 Code: | CAT010 |
| Area Code Type: | Area Code |
| Area Code: | 03833 |
| Blank Name Sec1: | Patron saint |
| Blank Info Sec1: | ? |
Fray Mamerto Esquiú is a department of Catamarca Province in Argentina. This provincial subdivision has a population of about 11,000 inhabitants in an area of, and its capital city is San José. The department is named after friar Mamerto Esquiú (1826-1883).