| Franquelis Osoria | |
| Position: | Relief pitcher |
| Bats: | Right |
| Throws: | Right |
| Birth Date: | 12 September 1981 |
| Birth Place: | Santiago, Dominican Republic |
| Debutleague: | MLB |
| Debutdate: | June 7 |
| Debutyear: | 2005 |
| Debutteam: | Los Angeles Dodgers |
| Finalleague: | MLB |
| Finaldate: | July 30 |
| Finalyear: | 2008 |
| Finalteam: | Pittsburgh Pirates |
| Statleague: | MLB |
| Stat1label: | Win–loss record |
| Stat1value: | 4–9 |
| Stat2label: | Earned run average |
| Stat2value: | 5.48 |
| Stat3label: | Strikeouts |
| Stat3value: | 72 |
| Teams: | |
Franquelis Antonio Osoria (born September 12, 1981) is a retired Major League Baseball pitcher.
Osoria made his Major League Baseball debut with the Los Angeles Dodgers on June 7, . In December, he was claimed off waivers by the Pittsburgh Pirates. After spending most of the season with the Pirates' Triple-A club in Indianapolis, going 2-5 with a 2.63 ERA in 39 games as a reliever, he was called up by the Pirates on August 4, . On July 31,, he was designated for assignment after the Pirates traded Jason Bay for four players. On November 30, 2008, he signed a minor league contract with the Kansas City Royals.
Like fellow reliever Antonio Alfonseca, Osoria has an extra digit on his throwing hand.