| Birth Date: | June 15, 1924 |
| Birth Place: | Footedale, Pennsylvania, U.S. |
| Position1: | OT / DT |
| College: | Cornell |
| Nfldraftedyear: | 1947 |
| Nfldraftedround: | 5 / Pick 29 |
| Playing Years1: | 1947–1951 |
| Playing Team1: | Pittsburgh Steelers |
| Playing Years2: | 1952–1957 |
| Playing Team2: | Philadelphia Eagles |
| Career Highlights: |
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| Databasefootball: | WYDOFRA01 |
Frank Wydo (June 15, 1924February 17, 1979) was an American football tackle who played eleven seasons in the National Football League (NFL) for the Pittsburgh Steelers and the Philadelphia Eagles.