| Birth Date: | 15 February 1921 |
| Birth Place: | Mendota, Illinois, U.S. |
| Death Place: | Bellwood, Illinois, U.S. |
| Number: | 25 |
| Position1: | Running back Defensive back |
| College: | George Washington |
| Playing Years1: | 1943–1944 |
| Playing Team1: | Washington Redskins |
| Playing Years2: | 1945–1946 |
| Playing Team2: | Chicago Cardinals |
| Playing Years3: | 1947–1948 |
| Playing Team3: | Boston Yanks |
| Playing Years4: | 1949 |
| Playing Team4: | Washington Redskins |
| Nfl: | SEN355962 |
| Databasefootball: | SENOFRA01 |
Frank Seno (February 15, 1921 - March 1974) was an American football running back and defensive back in the National Football League (NFL) for the Washington Redskins, the Chicago Cardinals, and the Boston Yanks. He attended George Washington University.