| Frank O'Keefe | |
| Fullname: | Francis Joseph O'Keefe |
| Birth Date: | 24 April 1898 |
| Birth Place: | South Melbourne, Victoria |
| Death Place: | Heidelberg, Victoria |
| Height: | 184 cm |
| Weight: | 82 kg |
| Guernsey: | 4 |
| Statsend: | 1916 |
| Years1: | 1916 |
| Games Goals1: | 1 (1) |
Francis Joseph O'Keefe (24 April 1898 – 26 June 1958) was an Australian rules footballer who played with Fitzroy in the Victorian Football League (VFL).[1]