| Frank Nicholson | |
| Position: | Pitcher |
| Bats: | Right |
| Throws: | Right |
| Birth Date: | 29 August 1889 |
| Birth Place: | Berlin, Pennsylvania, U.S. |
| Death Place: | Jersey Shore, Pennsylvania, U.S. |
| Debutleague: | MLB |
| Debutdate: | September 6 |
| Debutteam: | Philadelphia Phillies |
| Finalleague: | MLB |
| Finaldate: | September 10 |
| Finalteam: | Philadelphia Phillies |
| Statleague: | MLB |
| Stat1label: | Games |
| Stat1value: | 2 |
| Stat2label: | Innings pitched |
| Stat2value: | 4.0 |
| Stat3label: | Strikeouts |
| Stat3value: | 1 |
| Teams: | |
Frank Collins Nicholson (August 29, 1889 – November 10, 1972) was an American Major League Baseball pitcher who played for the Philadelphia Phillies in . He pitched in two games, posting a 6.75 ERA and earning one game finished.