| Frank Keffer | |
| Position: | Pitcher |
| Bats: | Unknown |
| Throws: | Unknown |
| Birth Date: | July 1, 1861 |
| Birth Place: | Lancaster, Pennsylvania, US |
| Death Date: | Harrisburg, Pennsylvania, US |
| Debutleague: | MLB |
| Debutdate: | April 19 |
| Debutyear: | 1890 |
| Debutteam: | Syracuse Stars |
| Finalleague: | MLB |
| Finaldate: | May 3 |
| Finalyear: | 1890 |
| Finalteam: | Syracuse Stars |
| Statleague: | MLB |
| Stat1label: | Win–loss record |
| Stat1value: | 1–1 |
| Stat2label: | Strikeouts |
| Stat2value: | 4 |
| Stat3label: | Earned run average |
| Stat3value: | 5.63 |
| Teams: |
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Charles Franklin Keffer (July 1, 1867 – April 17, 1923) was an American major league baseball player who played during the late 19th century. He was a pitcher for the Syracuse Stars of the American Association in April and May 1890, appearing in two games.