| Frank Griffith | |
| Position: | Pitcher |
| Bats: | Left |
| Throws: | Left |
| Birth Date: | November 18, 1872 |
| Birth Place: | Gilman, Illinois |
| Death Place: | Waterman, Illinois |
| Debutleague: | MLB |
| Debutdate: | August 13 |
| Debutyear: | 1892 |
| Debutteam: | Chicago Colts |
| Finalleague: | MLB |
| Finaldate: | July 17 |
| Finalyear: | 1894 |
| Finalteam: | Cleveland Spiders |
| Statleague: | MLB |
| Stat1label: | Win–loss record |
| Stat1value: | 1–3 |
| Stat2label: | Strikeouts |
| Stat2value: | 18 |
| Stat3label: | Earned run average |
| Stat3value: | 10.10 |
| Teams: |
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Frank Wesley Griffith (November 18, 1872 – December 8, 1908), was a professional baseball player who pitched in the Major Leagues for the 1892 Chicago Colts and 1894 Cleveland Spiders. He played college baseball at Northwestern University. He played in the minors in 1895 and 1896.