| Position: | Center, guard |
| Birth Date: | 11 January 1905 |
| Birth Place: | Minneapolis |
| Death Place: | Minneapolis |
| Weight Lbs: | 190 |
| High School: | North (MN) |
| Teams: |
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| Statlabel1: | Games |
| Statvalue1: | 3 |
Frank Otto Gause (February 11, 1905 – August 15, 1972) was an American football player. Gause was born in 1905 in Minneapolis. He was a star football player at Minneapolis' North High School in the early 1920s.[1] He played professional football in the National Football League (NFL) as a center and guard for the Minneapolis Red Jackets. He appeared in three NFL games, two as a starter, during the 1929 season.[2] He also played for the Ace Box Lunch team in 1931. He died in 1976 in Minneapolis.[2]