| Birth Date: | 4 October 1891 |
| Birth Place: | Copiah County, MS |
| Death Place: | Hazlehurst, Mississippi |
| State Senate: | Mississippi |
| Termstart: | January 1944 |
| Termend: | January 1960 |
| Party: | Democrat |
| District: | 11th |
| Predecessor: | Luther E. Grice |
| Successor: | S. B. Wise |
| Residence: | Crystal Springs, Mississippi |
Frank Downer Barlow (October 4, 1891 – June 12, 1982) was a Democratic Mississippi state senator, representing the state's 11th senatorial district from 1944 to 1960.
Frank Downer Barlow was born on October 4, 1891, in Barlow, Copiah County, Mississippi.[1] [2] He was a cattleman.[3] He first became a member of the Mississippi Senate, representing the 11th senatorial district (Copiah County) as a Democrat, in 1944 for the 1944-1948 term. He was re-elected for the next three terms, serving four terms in total, from 1944 to 1960. He died on June 12, 1982, in the Hardy Wilson Memorial Hospital in Hazlehurst, Mississippi.