| Frank Barnes | |
| Position: | Pitcher |
| Bats: | Left |
| Throws: | Left |
| Birth Date: | 9 January 1900 |
| Birth Place: | Dallas, Texas |
| Death Place: | Houston, Texas |
| Debutleague: | MLB |
| Debutdate: | April 18 |
| Debutyear: | 1929 |
| Debutteam: | Detroit Tigers |
| Finalleague: | MLB |
| Finaldate: | September 26 |
| Finalyear: | 1930 |
| Finalteam: | New York Yankees |
| Statleague: | MLB |
| Stat1label: | Win–loss record |
| Stat1value: | 0–2 |
| Stat2label: | Earned run average |
| Stat2value: | 7.79 |
| Stat3label: | Strikeouts |
| Stat3value: | 2 |
| Teams: | |
Frank Samuel "Lefty" Barnes (January 9, 1900 – September 27, 1967) was a Major League Baseball (MLB) pitcher. Barnes played for the Detroit Tigers in 1929 and the New York Yankees in 1930. In six career games, he had a 0–2 record, with a 7.79 earned run average.