| Type: | Bishop |
| Honorific-Prefix: | Most Reverend |
| Francisco de Zamudio y Avendaño | |
| Bishop of Nueva Caceres | |
| Church: | Catholic Church |
| Diocese: | Diocese of Nueva Caceres |
| Term: | 1628–1639 |
| Predecessor: | Luis de Cañizares |
| Successor: | Nicolás de Zaldívar y Zapata |
| Consecration: | 29 June 1629 |
| Birth Date: | 7 January 1570 |
| Birth Place: | Portilla, Spanish Empire |
| Death Date: | 27 April 1639 (age 69) |
| Death Place: | Nueva Caceres, Captaincy General of the Philippines |
Francisco de Zamudio y Avendaño, O.S.A. (7 January 1570 – 27 April 1639) was a Roman Catholic prelate who served as Bishop of Nueva Caceres (1628–1639).[1]
Francisco de Zamudio y Avendaño was born in Portilla on 7 January 1570 and ordained a priest in the Order of Saint Augustine.[2] On 10 July 1628, he was appointed during the papacy of Pope Urban VIII as Bishop of Nueva Caceres.On 29 June 1629, he was consecrated bishop. He served as Bishop of Nueva Caceres until his death on 10 July 1639.