| Francisco Téllez-Girón, 10th Duke of Osuna | |
| Spouse: | Marie-Françoise-Philippine Beaufort-Spontin |
| Issue: | Pedro de Alcántara Téllez-Girón y Beaufort Spontin, 14th Duke of the Infantado |
| Noble Family: | House of Osuna |
| Father: | Pedro Téllez-Girón, 9th Duke of Osuna |
| Mother: | María Josefa Pimentel, Duchess of Osuna |
| Birth Date: | 6 October 1785 |
Francisco de Borja Téllez-Girón y Pimentel, 10th Duke de Osuna, Grandee of Spain (in full, Spanish; Castilian: [[Don (honorific)|Don]] Francisco de Borja Bruno Téllez-Girón y Alfonso Pimentel, décimo duque de Osuna, décimo cuarto conde de Ureña, décimo primer marqués de Peñafiel, señor de la villa de Morón de la Frontera, Archidona, El Arahal, Olvera, Ortejicar, Cazalla de la Sierra, Tiedra, Gumiel de Izán al Inza, y Briones, conde de Fontanar, camarero mayor del Rey, Notario mayor de los Reinos de Castilla, conde-duque de Benavente, Béjar, Gandía, los Arcos, conde de Mayorga, Belacázar, marqués de Lombay, de Zahara, duca di Montacuto en Cerdeña, primer teniente del Regimiento de Reales Guardias de Infantería española, teniente coronel del Regimiento de Voluntarios de la Corona, caballero de Calatrava (1796), [[Gran Cruz de la Orden de Carlos III]], [[Gentilhombres Grandes de España con ejercicio y servidumbre|gentilhombre de cámara con ejercicio y servidumbre]] de Carlos IV y Fernando VII), (6 October 1785 – 21 May 1820), was a Spanish nobleman.
Francisco Téllez-Girón was the 7th son of Pedro Téllez-Girón, 9th Duke of Osuna (1756–1807) and was the 10th Duke of Osuna since 1807. He married in 1802, Countess Marie Françoise Philippine Beaufort-Spontin (1785–1830), daughter of Frederic Augustus Alexander, Duke of Beaufort-Spontin and his wife Leopoldina Álvarez de Toledo (1760–1792), who in turn was the daughter of Pedro de Alcántara Álvarez de Toledo y Silva, 12th Duke of the Infantado.Their son the 11th Duke, Pedro de Álcantara was born in 1810, but died in 1844 without issue.