| Type: | Bishop |
| Honorific-Prefix: | Most Reverend |
| Francisco Rodríguez de Valcárcel | |
| Church: | Catholic Church |
| Term: | 1649–1651 |
| Predecessor: | Cristóbal Pérez Lazarraga y Maneli Viana |
| Successor: | Garcia Ruiz Cabezas |
| Birth Date: | 23 May 1590 |
| Birth Place: | Zamora, Spain |
| Death Date: | 18 Jun 1651 (age 61) |
Francisco Rodríguez de Valcárcel (23 May 1590 – 18 Jun 1651) was a Roman Catholic prelate who served as Bishop of Cartagena (1649–1651).
Francisco Rodríguez de Valcárcel was born on 23 May 1590 in Zamora, Spain.On 28 Jun 1649, he was appointed during the papacy of Pope Innocent X as Bishop of Cartagena.On 4 Sep 1650, he was consecrated bishop by Juan de Espinoza y Orozco, Bishop of Santa Marta.He served as Bishop of Cartagena until his death on 18 Jun 1651.