| Honorific-Prefix: | Most Reverend |
| Francisco Pio Guadalupe Tellez | |
| Archbishop of Santo Domingo | |
| Church: | Catholic Church |
| Archdiocese: | Archdiocese of Santo Domingo |
| Term: | 1648–1660 |
| Predecessor: | Maestro Valderas |
| Successor: | Francisco de la Cueva Maldonado |
| Consecration: | 1649 |
| Consecrated By: | Ramón Sentmenat y Lanuza |
| Death Date: | 5 March 1660 |
| Death Place: | Santo Domingo |
Francisco Pio Guadalupe Téllez (died 5 March 1660) was a Roman Catholic prelate who served as Archbishop of Santo Domingo (1648–1660).[1]
On 23 November 1648, Francisco Pio Guadalupe Téllez was selected by the King of Spain and confirmed by Pope Innocent X as Archbishop of Santo Domingo. In 1649, he was consecrated bishop by Ramón Sentmenat y Lanuza, Bishop of Vic with Timoteo Pérez Vargas, Bishop Emeritus of Baghdad, and Blas Tineo Palacios, Auxiliary Bishop of Granada, as co-consecrators. He served as Archbishop of Santo Domingo until his death on 5 March 1660. His Vicar General was García Polanco[2]