| Francisco Antonio Pérez | |
| Office: | President of Government Junta |
| Term Start: | April 13, 1813 |
| Term End: | August 23, 1813 |
| Predecessor: | José Miguel Carrera |
| Successor: | José Miguel Infante |
| Birth Name: | Francisco Antonio Pérez Salas |
| Birth Place: | Santiago, Captaincy General of Chile, Spanish Empire |
Francisco Antonio Pérez Salas (1764 – November 10, 1828) was a Chilean political figure. He served several times as member of different Government Juntas, and participated actively in the war of independence in that country.
He was born in Santiago, the son of José Pérez García and of Ana Josefa Ramirez de Salas y Pavón. Pérez studied law and was admitted to practice in colonial Chile. He was a member of the Government Junta established on April 13, 1813, together with Agustín Eyzaguirre and José Miguel Infante. He was president of the junta between April 13 and August 23, and remained a member until October 9 of the same year. He is one of the founders of the National Library of Chile.
During the period of the Spanish Reconquista, he was arrested and imprisoned in Juan Fernández island. After the battle of Chacabuco he was set free, and became a member and later the regent of the Justice Chamber. He was elected a Senator in 1822 and died in Santiago in 1828.