Francis Willoughby, 3rd Baron Middleton (25 January 1726 – 16 December 1774), was an English nobleman, the eldest son of Francis Willoughby, 2nd Baron Middleton.
He was educated at Bury St Edmund's School, and entered Jesus College, Cambridge, in 1744.[1] He succeeded his father in 1768, inheriting the family seat at Wollaton Park, Nottinghamshire, where he subsequently lived.
He died unmarried[2] and was succeeded by his younger brother, Thomas Willoughby, 4th Baron Middleton.