| Francis Preston | |
| Office1: | Member of the Virginia Senate from Botetourt, Cabell, Giles, Grayson, Greenbrier, Kanawha, Lee, Mason Monroe, Montgomery, Russell, Scott, Tazewell, Washington and Wythe Counties |
| Term1: | 1816–1819 |
| Predecessor1: | Henley Chapman |
| Successor1: | District abolished |
| Office2: | Member of the Virginia House of Delegates from Washington County |
| Term2: | 1812–1813 Alongside Reuben Bradley |
| Office3: | Member of the Virginia House of Delegates from Montgomery County |
| Term3: | 1788–1789 Alongside Daniel Trigg, Walter Crockett |
| State4: | Virginia |
| District4: | 4th |
| Term Start4: | March 4, 1793 |
| Term End4: | March 3, 1797 |
| Preceded4: | Richard Bland Lee |
| Successor4: | Abram Trigg |
| Birth Date: | 2 August 1765 |
| Birth Place: | Greenfield, Virginia |
| Death Place: | Columbia, South Carolina |
| Resting Place: | Seven Mile Ford, Virginia |
| Party: | Anti-Administration until 1795 |
| Otherparty: | Democratic-Republican after 1795 |
| Alma Mater: | The College of William and Mary |
| Battles: | War of 1812 |
| Rank: | Colonel |
| Branch: | Virginia state militia |
Francis Preston (August 2, 1765 – May 26, 1835) was an American lawyer and politician from Abingdon, Virginia. He was the son of Col. William Preston of Virginia, served in both houses of the state legislature, and represented Virginia in the U.S. House of Representatives from 1793 to 1797.[1] Preston had a house built in Abingdon, now called the Martha Washington Inn. In 1795, while residing at Saltville, he constructed the Preston House.[2]
Preston was the father of Isaac Trimble Preston, William Campbell Preston, and John S. Preston and the uncle of William Ballard and William Preston. His daughter Sarah (Sally) Buchanan Preston (1802–1879) married her cousin Virginia Governor John B. Floyd.