| Francesco IV Gonzaga | |
| Succession: | Duke of Mantua and Montferrat |
| Reign: | 9 February 1612 - 22 December 1612 |
| Predecessor: | Vincenzo I Gonzaga |
| Successor: | Ferdinando Gonzaga |
| House: | Gonzaga |
| Father: | Vincenzo I Gonzaga |
| Mother: | Eleonora de' Medici |
| Issue: | Maria Gonzaga |
| Birth Place: | Mantua, Duchy of Mantua |
| Death Place: | Mantua, Duchy of Mantua |
Francesco IV Gonzaga (7 May 1586 – 22 December 1612) was duke of Mantua and Montferrat between 9 February and 22 December 1612.
Born in Mantua, he was the eldest son of Duke Vincenzo I and Eleonora de' Medici.
In 1607, Claudio Monteverdi dedicated his opera L'Orfeo to Francesco. The title page of the opera bears the dedication "Al serenissimo signor D. Francesco Gonzaga, Prencipe di Mantoua, & di Monferato, &c."
Francesco became Duke upon his father's death on 9 February 1612. He died at Mantua on 22 December 1612 without male heirs. He was succeeded by his brother Ferdinand; however, Charles Emmanuel I, Duke of Savoy, the father of Francesco's wife Margaret of Savoy, disputed this, leading to the War of the Montferrat Succession (1613–1617).
On 19 February 1608 he married in Turin, Margaret of Savoy (1589–1655), daughter of Charles Emmanuel I, Duke of Savoy. They had:
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