| Francis Ernest of Hesse-Darmstadt | |
| Father: | Ernest Louis, Landgrave of Hesse-Darmstadt |
| Mother: | Dorothea Charlotte of Brandenburg-Ansbach |
| Birth Date: | 25 January 1695 |
| Birth Place: | Gießen |
| Death Place: | Darmstadt |
Francis Ernest of Hesse-Darmstadt (born 25 January 1695 in Gießen; died: 8 January 1716 in Darmstadt) was a German nobleman.
He was the third son of Count Landgrave Ernest Louis of Hesse-Darmstadt (1667–1739) from his marriage to Dorothea Charlotte (1661–1705), daughter of the Margrave Albert of Brandenburg-Ansbach.[1]
He replaced his brother Charles William of Hesse-Darmstadt as Colonel of the Hesse-Darmstadt Kreis Regiment when Charles William died during the War of Spanish Succession.