| Type: | Bishop |
| Honorific-Prefix: | Most Reverend |
| Francesco Spera | |
| Titular Archbishop of Nazareth | |
| Church: | Catholic Church |
| Term: | 1587 |
| Predecessor: | Fabio Mirto Frangipani |
| Successor: | Girolamo Bevilacqua |
| Consecration: | 24 May 1587 |
| Consecrated By: | Decio Azzolini (seniore) |
| Death Date: | 28 October 1587 |
Francesco Spera, O.F.M. (died 1587) was a Roman Catholic prelate who served as Titular Archbishop of Nazareth (1587).[1]
Francesco Spera was ordained a priest in the Order of Friars Minor.On 11 May 1587, he was appointed during the papacy of Pope Sixtus V as Titular Archbishop of Nazareth.On 24 May 1587, he was consecrated bishop by Decio Azzolini (seniore), Bishop of Cervia, with Francesco Carusi, Bishop of Valva e Sulmona, and Franciscus Panicarola, Titular Bishop of Chrysopolis in Arabia, serving as co-consecrators. He served as Titular Archbishop of Nazareth until his death on 28 October 1587.