| Type: | Bishop |
| Honorific-Prefix: | Most Reverend |
| Francesco Piccolomini | |
| Bishop of Grosseto | |
| Church: | Catholic Church |
| Diocese: | Diocese of Grosseto |
| Term: | 1611–1622 |
| Predecessor: | Giulio Sansedoni |
| Successor: | Girolamo Tantucci |
| Consecration: | 6 November 1611 |
| Consecrated By: | Giovanni Garzia Mellini |
| Death Date: | May 1622 |
| Death Place: | Grosseto, Italy |
Francesco Piccolomini (died 1622) was a Roman Catholic prelate who served as Bishop of Grosseto (1611–1622).
On 17 August 1611, Francesco Piccolomini was appointed during the papacy of Pope Paul V as Bishop of Grosseto.[1] On 6 November 1611, he was consecrated bishop by Giovanni Garzia Mellini, Cardinal-Priest of Santi Quattro Coronati, with Alessandro Borghi (bishop), Bishop Emeritus of Sansepolcro, and Antonio Maria Franceschini, Bishop of Amelia, serving as co-consecrators. He served as Bishop of Grosseto until his death in May 1622. While bishop, he was the principal co-consecrator of Gregorio Pomodoro, Bishop of Larino (1616) .