| Type: | Cardinal |
| Francesco Maria Macchiavelli | |
| Cardinal, Bishop of Ferrara | |
| Church: | Catholic Church |
| Appointed: | 11 October 1638 |
| Ended: | 22 November 1653 |
| Predecessor: | Lorenzo Magalotti |
| Successor: | Carlo Pio di Savoia |
| Consecration: | 1639 (Bishop) |
| Birth Place: | Florence |
| Cardinal: | 16 December 1641 |
| Death Place: | Ferrara |
Francesco Maria Macchiavelli (1608 – 22 November 1653) was an Italian Catholic cardinal. Born in Florence, he was bishop of Ferrara from 1638 to 1653.
He was made a cardinal on the 16 December 1641 by Pope Urban VIII, was the nephew of cardinal Lorenzo Magalotti and the cousin of cardinals Francesco Barberini the elder and Antonio Barberini the younger.
He died at Ferrara in 1653.