| Order: | 168th Doge of the Republic of Genoa |
| Term Start1: | 29 January 1765 |
| Term End1: | 29 January 1767 |
| Predecessor1: | Rodolfo Emilio Brignole Sale |
| Successor1: | Marcello Durazzo |
| Birth Date: | 13 February 1695 |
| Birth Place: | Genoa, Republic of Genoa |
| Death Date: | 23 May 1768 |
| Death Place: | Genoa, Republic of Genoa |
Francesco Maria Della Rovere (Genoa, 13 February 1695 - Genoa, 23 May 1768) was the 168th Doge of the Republic of Genoa, the last member of the Genoese branch of the Della Rovere family.
During his mandate as Doge of Genoa, he commissioned new conservation and restoration works for the Doge's Palace, the residence of the doge in charge and seat of political power for the presence of the Major and Minor Council of the Republic of Genoa. He also maintained good relations with the Holy See in Rome and also thanks to his Roman knowledge he favored the cardinal election of the Genoese Nicolò Serra and Lazzaro Pallavicini. When the dogal office ended on 29 January 1767, Francesco Maria Della Rovere died in Genoa on 23 May 1768. Having had no children from his wife Caterina Negrone, daughter of the former doge Domenico Negrone, the Genoese noble branch of the Della Rovere family went extinct.