| Francesco De Francesco | |
| Birth Date: | 21 September 1977 |
| Birth Place: | Tortora, Italy |
| Height: | 1.77 m |
| Position: | Striker |
| Youthyears1: | 1992–1995 |
| Youthclubs1: | Milan |
| Years1: | 1995–1997 |
| Years2: | 1997–1998 |
| Years3: | 1998 |
| Years4: | 1999 |
| Years5: | 1999 |
| Years6: | 2000–2001 |
| Years7: | 2001–2002 |
| Years8: | 2002–2003 |
| Years9: | 2003–2004 |
| Years10: | 2004–2005 |
| Years11: | 2005–2006 |
| Clubs1: | Prato |
| Clubs2: | Lecce |
| Clubs3: | Salernitana |
| Clubs4: | Cosenza |
| Clubs5: | Salernitana |
| Clubs6: | Cosenza |
| Clubs7: | Treviso |
| Clubs8: | Genoa |
| Clubs9: | Como |
| Clubs10: | SPAL |
| Clubs11: | Cremonese |
| Caps1: | 46 |
| Caps2: | 19 |
| Caps3: | 0 |
| Caps4: | 13 |
| Caps5: | 1 |
| Caps6: | 31 |
| Caps7: | 20 |
| Caps8: | 21 |
| Caps9: | 10 |
| Totalcaps: | 176 |
| Caps10: | 9 |
| Caps11: | 6 |
| Goals1: | 9 |
| Goals2: | 0 |
| Goals3: | 0 |
| Goals4: | 4 |
| Goals5: | 0 |
| Goals6: | 5 |
| Goals7: | 3 |
| Goals8: | 4 |
| Goals9: | 1 |
| Goals10: | 0 |
| Goals11: | 0 |
| Totalgoals: | 26 |
| Nationalyears1: | 1992 |
| Nationalyears2: | 1993–1994 |
| Nationalyears3: | 1995 |
| Nationalyears4: | 1994–1996 |
| Nationalteam1: | Italy U-15 |
| Nationalteam2: | Italy U-16 |
| Nationalteam3: | Italy U-17 |
| Nationalteam4: | Italy U-18 |
| Nationalcaps1: | 4 |
| Nationalcaps2: | 3 |
| Nationalcaps3: | 3 |
| Nationalcaps4: | 15 |
| Nationalgoals1: | 1 |
| Nationalgoals2: | 1 |
| Nationalgoals3: | 2 |
| Nationalgoals4: | 10 |
Francesco De Francesco (born 21 September 1977, in Tortora) is a retired Italian professional footballer who played as a striker.
He played 19 games in the 1997–98 season for U.S. Lecce in the Italian Serie A.
He represented the Italy U-17 side at the 1993 FIFA U-17 World Championship.