| Type: | Bishop |
| Honorific-Prefix: | Most Reverend |
| Francesco D'Afflitto | |
| Bishop of Scala | |
| Church: | Catholic Church |
| Diocese: | Diocese of Scala |
| Term: | 1583–1593 |
| Predecessor: | Feliciano Ninguarda |
| Successor: | Giovanni Battista Serignano |
| Consecration: | 13 November 1583 |
| Consecrated By: | Giulio Rossino |
| Death Date: | 11 October 1593 |
| Death Place: | Scala, Italy |
Francesco D'Afflitto (died 11 October 1593) was a Roman Catholic prelate who served as Bishop of Scala (1583–1593).[1] He descends from the princely house d’Afflitto.
On 27 June 1583, Francesco D'Afflitto was appointed during the papacy of Pope Gregory XIII as Bishop of Scala. On 13 November 1583, he was consecrated bishop by Giulio Rossino, Archbishop of Amalfi, with Giovanni Bernardino Grandopoli, Bishop of Lettere-Gragnano, and Giovanni Agostino Campanile, Bishop of Minori, serving as co-consecrators. He served as Bishop of Scala until his death on 11 October 1593.