Frances Brodsky Explained

Honorific Prefix:Professor
Frances Brodsky
Honorific Suffix:DPhil FMedSci
Nationality:American
Workplaces:University College, London
University of California, San Francisco
Alma Mater:Harvard University
University of Oxford
Thesis1 Title:and
Thesis2 Title:)-->
Thesis1 Url:and
Thesis2 Url:)-->
Thesis1 Year:and
Thesis2 Year:)-->
Doctoral Advisor:Walter Bodmer
Jack Strominger
Known For:Studies of clathrin and vesicle trafficking
Spouses:)-->
Partners:)-->

Frances Brodsky is an American cell biologist. She is known for her work on clathrin and its role in the function of the immune system.[1] She is a professor of cell biology and the director of the Division of Biosciences (part of the Faculty of Life Sciences) at University College London. She is the author of three scientific mystery novels under the pseudonym B.B. Jordan. She was the founding editor of the journal Traffic.[2]

Education

Brodsky earned her B.Sc. in biochemistry from Harvard University in 1976. She received a Marshall Scholarship to study in the UK and performed research in the laboratory of Walter Bodmer at Oxford University, obtaining a D. Phil. (Oxford's term for a Ph.D.) in 1979.

Career

After postdoctoral work at Harvard University and Stanford University, Brodsky joined Becton Dickinson as a program manager in cell biology in 1982. In 1987, she returned to academia as an assistant professor in the Department of Pharmacy and Pharmaceutical Chemistry at the University of California, San Francisco.

Brodsky's work straddles the interface of immunology and cell biology. She developed some of the first monoclonal antibodies to the major histocompatibility complex, a protein that is central to the immune system.[3] [4] She became interested in clathrin, a protein that is key to both inward and outward membrane trafficking in cells, shortly after its isolation by Barbara Pearse. She used monoclonal antibodies to map the structure of clathrin[5] [6] and to probe its assembly into its characteristic polyhedral structures.[7] [8] Clathrin-mediated endocytosis is involved in the uptake of antigens from outside the cell that are eventually presented on the surface of the cell by the major histocompatibility complex class II (MHC class II). Brodsky discovered that the pathway of MHC class II export meets the antigen import pathway in a specialized endocytic compartment where antigens can be processed into peptides and loaded onto the MHC class II molecule for presentation.[9] She also identified the site at which peptides are loaded onto MHC class I proteins.[10]

Brodsky has been a leader in analyzing the regulation of clathrin assembly[11] [12] [13] and the adaptor proteins that help capture specific cargoes in clathrin-coated vesicles.[14] [15] She has identified roles for clathrin isoforms in diseases such as diabetes[16] and myopathies,[17] and in controlling immunoglobulin class switching.[18]

In 2000, she founded Traffic: The International Journal of Intracellular Transport with Mark Marsh, Sandra Schmid, and Thomas Kreis, with the goal of creating “a central journal to gather together publications that are of most interest to those working on intracellular trafficking”. In 2007, she stepped aside from the role of co-Editor to become Reviews Editor of Traffic.[19]

In 2015, after 28 years at UCSF, Brodsky moved back to the UK to lead the Division of Biosciences at University College London.[20]

In 2019, she was elected to the council of the Academy of Medical Sciences[21]

Awards

Mystery novels

Brodsky is the author of three mystery novels starring virologist Dr. Celeste Braun, all published by Berkley Prime Crime, under the pseudonym B.B. Jordan. In Principal Investigation (1997),[24] Braun foils a criminal who is threatening to cause an outbreak of a deadly virus; in Secondary Immunization (1999)[25] she uncovers a conspiracy that uses the immune systems of patients to carry information for a drug cartel; and in Triplet Code (2001)[26] she solves the mystery of the deaths of three colleagues.

External links

Notes and References

  1. Sedwick. Caitlin. 2013-09-16. Frances Brodsky: So you think you know all about clathrin?. The Journal of Cell Biology. 202. 6. 830–831. 10.1083/jcb.2026pi. 0021-9525. 3776341. 24043697.
  2. Jahn. Reinhard. 2000. Green and red lights at the cell. Nature. en. 407. 6802. 299. 10.1038/35030250. 5245312 . 0028-0836. free.
  3. Parham. P.. Sehgal. P. K.. Brodsky. F. M.. 1979-06-14. Anti-HLA-A,B,C monoclonal antibodies with no alloantigenic specificity in humans define polymorphisms in other primate species. Nature. 279. 5714. 639–641. 0028-0836. 88017. 10.1038/279639a0. 1979Natur.279..639P. 4255372 .
  4. Brodsky. F. M.. Bodmer. W. F.. Parham. P.. 1979. Characterization of a monoclonal anti-beta 2-microglobulin antibody and its use in the genetic and biochemical analysis of major histocompatibility antigens. European Journal of Immunology. 9. 7. 536–545. 10.1002/eji.1830090709. 0014-2980. 91522. 45088807 .
  5. Brodsky. F. M.. 1985. Clathrin structure characterized with monoclonal antibodies. I. Analysis of multiple antigenic sites. The Journal of Cell Biology. 101. 6. 2047–2054. 0021-9525. 2114023. 2415533. 10.1083/jcb.101.6.2047.
  6. Brodsky. F. M.. 1985. Clathrin structure characterized with monoclonal antibodies. II. Identification of in vivo forms of clathrin. The Journal of Cell Biology. 101. 6. 2055–2062. 0021-9525. 2114020. 4066749. 10.1083/jcb.101.6.2055.
  7. Blank. G. S.. Brodsky. F. M.. 1986. Site-specific disruption of clathrin assembly produces novel structures. The EMBO Journal. 5. 9. 2087–2095. 0261-4189. 1167086. 3096714. 10.1002/j.1460-2075.1986.tb04470.x.
  8. Brodsky. F. M.. Galloway. C. J.. Blank. G. S.. Jackson. A. P.. Seow. H. F.. Drickamer. K.. Parham. P.. 1987. Localization of clathrin light-chain sequences mediating heavy-chain binding and coated vesicle diversity. Nature. 326. 6109. 203–205. 10.1038/326203a0. 0028-0836. 2434865. 1987Natur.326..203B. 4363913 .
  9. Guagliardi. L. E.. Koppelman. B.. Blum. J. S.. Marks. M. S.. Cresswell. P.. Brodsky. F. M.. 1990-01-11. Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment. Nature. 343. 6254. 133–139. 10.1038/343133a0. 0028-0836. 2404209. 1990Natur.343..133G. 4240003 .
  10. Bresnahan. P. A.. Barber. L. D.. Brodsky. F. M.. 1997-04-01. Localization of class I histocompatibility molecule assembly by subfractionation of the early secretory pathway. Human Immunology. 53. 2. 129–139. 10.1016/S0198-8859(97)00001-3. 0198-8859. 9129970.
  11. Liu. S. H.. Wong. M. L.. Craik. C. S.. Brodsky. F. M.. 1995-10-20. Regulation of clathrin assembly and trimerization defined using recombinant triskelion hubs. Cell. 83. 2. 257–267. 0092-8674. 7585943. 10.1016/0092-8674(95)90167-1. free.
  12. Stoddart. Angela. Dykstra. Michelle L.. Brown. Bruce K.. Song. Wenxia. Pierce. Susan K.. Brodsky. Frances M.. 2002. Lipid rafts unite signaling cascades with clathrin to regulate BCR internalization. Immunity. 17. 4. 451–462. 1074-7613. 12387739. 10.1016/S1074-7613(02)00416-8. free.
  13. Wakeham. Diane E.. Chen. Chih-Ying. Greene. Barrie. Hwang. Peter K.. Brodsky. Frances M.. 2003-10-01. Clathrin self-assembly involves coordinated weak interactions favorable for cellular regulation. The EMBO Journal. 22. 19. 4980–4990. 10.1093/emboj/cdg511. 0261-4189. 204494. 14517237.
  14. Greene. B.. Liu. S. H.. Wilde. A.. Brodsky. F. M.. 2000. Complete reconstitution of clathrin basket formation with recombinant protein fragments: adaptor control of clathrin self-assembly. Traffic. 1. 1. 69–75. 1398-9219. 11208061. 10.1034/j.1600-0854.2000.010110.x. free.
  15. Knuehl. Christine. Chen. Chih-Ying. Manalo. Venus. Hwang. Peter K.. Ota. Nobuyuki. Brodsky. Frances M.. 2006. Novel binding sites on clathrin and adaptors regulate distinct aspects of coat assembly. Traffic. 7. 12. 1688–1700. 10.1111/j.1600-0854.2006.00499.x. 1398-9219. 17052248. free.
  16. Vassilopoulos. Stéphane. Esk. Christopher. Hoshino. Sachiko. Funke. Birgit H.. Chen. Chih-Ying. Plocik. Alex M.. Wright. Woodring E.. Kucherlapati. Raju. Brodsky. Frances M.. 2009-05-29. A role for the CHC22 clathrin heavy-chain isoform in human glucose metabolism. Science. 324. 5931. 1192–1196. 10.1126/science.1171529. 1095-9203. 2975026. 19478182. 2009Sci...324.1192V.
  17. Hoshino. Sachiko. Sakamoto. Kazuho. Vassilopoulos. Stéphane. Camus. Stéphane M.. Griffin. Christine A.. Esk. Christopher. Torres. Jorge A.. Ohkoshi. Norio. Ishii. Akiko. 2013. The CHC22 clathrin-GLUT4 transport pathway contributes to skeletal muscle regeneration. PLOS ONE. 8. 10. e77787. 10.1371/journal.pone.0077787. 1932-6203. 3813726. 24204966. 2013PLoSO...877787H. free .
  18. Wu. Shuang. Majeed. Sophia R.. Evans. Timothy M.. Camus. Marine D.. Wong. Nicole M. L.. Schollmeier. Yvette. Park. Minjong. Muppidi. Jagan R.. Reboldi. Andrea. 2016. Clathrin light chains' role in selective endocytosis influences antibody isotype switching. Proceedings of the National Academy of Sciences of the United States of America. 113. 35. 9816–9821. 10.1073/pnas.1611189113. 1091-6490. 5024586. 27540116. free .
  19. Brodsky. Frances M.. Marsh. Mark. 2010. Life History of the Journal TRAFFIC, Celebrating Ten Years of Publication. Traffic. en. 11. 1. 1–3. 10.1111/j.1600-0854.2009.01004.x. free.
  20. Web site: Department Says Farewell to Frances Brodsky School of Pharmacy UCSF. pharmacy.ucsf.edu. 13 November 2015 . 2019-03-17.
  21. Web site: Academy of Medical Sciences Council Members 2019. 2019-07-27.
  22. Web site: Frances Brodsky. en-US. 2019-03-17.
  23. Web site: Women in Cell Biology Awards. ASCB. en-US. 2019-03-17.
  24. Book: Jordan, B. B.. Principal investigation. 1997. Berkley Prime Crime. 978-0425160909. New York. 37832200.
  25. Book: Jordan, B. B.. Secondary immunization. 1999. Berkley Prime Crime. 978-0425171189. New York. 42654221. registration.
  26. Book: Jordan, B. B.. Triplet code. 2001. Berkley Prime Crime. 978-0425179208. New York. 46718397.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Frances Brodsky".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.