Franca Ronchese Explained

Franca Ronchese
Birth Place:	Italy
Fields:	Immunology
Workplaces:	National Institutes of Health Basel Institute for Immunology Malaghan Institute
Alma Mater:	University of Padua
Doctoral Students:	Dianne Sika-Paotonu^[1]
Awards:	Burnet Oration
Spouse:	Graham Le Gros

Franca Ronchese is an Italian-New Zealand immunologist. She currently leads the immune cell biology programme at the Malaghan Institute of Medical Research in Wellington, New Zealand and is a research professor at Victoria University of Wellington.^[2]

Career

After a PhD at the University of Padua, Italy, Ronchese worked as a postdoctoral fellow in the laboratory of Ronald Germain at the National Institutes of Health in the United States. After her postdoctoral studies, she joined the Basel Institute for Immunology, Switzerland, where she became interested in antigen presentation by dendritic cells in vivo. In 1994, Ronchese moved to New Zealand to establish her research programme at the Malaghan Institute of Medical Research, with a focus on developing immune therapies for cancer and allergies. Her current research focuses on dendritic cells^[3] (a kind of immune cell), and includes allergic response work.^{[4] [5] [6]}

In 2012, Ronchese was a finalist in the NEXT Woman of the Year.^[7] In 2018, she was invited to give the Australian and New Zealand Society for Immunology's Burnet Oration.^[8]

Personal life

Ronchese is married to Graham Le Gros, research director of the Malaghan Institute.^[9]

Selected publications

• Racioppi . Luigi . Franca . Ronchese . Louis A.. Matis . R. N. . Germain . Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling . . 177 . 4 . 1993 . 1047–1060. 10.1084/jem.177.4.1047 . 8384651 . 2190984 .
• Harris . Nicola L. . Victoria . Watt . Franca . Ronchese . Graham . Le Gros . Differential T cell function and fate in lymph node and nonlymphoid tissues . Journal of Experimental Medicine . 195 . 3 . 2002 . 317–326. 10.1084/jem.20011558 . 11828006 . 2193599 .
• Harris . Nicola L. . Franca . Ronchese . The role of B7 costimulation in T-cell immunity . . 77 . 4 . 1999 . 304–311 . 10.1046/j.1440-1711.1999.00835.x . 10457196 . 25675608 . free .
• Hermans . Ian F. . David S. . Ritchie . Jianping . Yang . Joanna M. . Roberts . Franca . Ronchese . CD8+ T cell-dependent elimination of dendritic cells in vivo limits the induction of antitumor immunity . . 164 . 6 . 2000 . 3095–3101. 10.4049/jimmunol.164.6.3095 . 10706699 . 22010635 . free .
• Harris . Nicola L. . Victoria . Watt . Franca . Ronchese . Graham . Le Gros . Differential T cell function and fate in lymph node and nonlymphoid tissues . Journal of Experimental Medicine . 195 . 3 . 2002 . 317–326. 10.1084/jem.20011558 . 11828006 . 2193599 .
• Ohta . Akio . Elieser . Gorelik . Simon J. . Prasad . Franca . Ronchese . Dmitriy . Lukashev . Michael K. K. . Wong . Xiaojun . Huang . etal . A2A adenosine receptor protects tumors from antitumor T cells . . 103 . 35 . 2006 . 13132–13137. 10.1073/pnas.0605251103 . 16916931 . 1559765 . 2006PNAS..10313132O . free .
• Prout . M. S. . Kyle . R.L. . Ronchese . F. . Le Gros . G. . 2018 . IL-4 is a key requirement for IL-4 and IL-4/IL-13 expressing CD4 Th2 subsets in lung and skin . . 9 . 1211. 10.3389/fimmu.2018.01211 . 29910811 . 5992292 . free .
• Gilfillan . C. B. . Kuhn . S. . Baey . C. . Hyde . E. J. . Yang . J. . Ruedl . C. . Ronchese . F. . 2018 . Clec9A+ dendritic cells are not essential for antitumor CD8+ T cell responses induced by poly I:C immunotherapy . Journal of Immunology. 200 . 8 . 2978–2986 . 10.4049/jimmunol.1701593 . 29507107 . 4716259 . free .
• Hilligan . K. L. . Ronchese . F. . 2020 . Antigen presentation by dendritic cells and their instruction of CD4+ T helper cell responses . . 17 . 6 . 587–599. 10.1038/s41423-020-0465-0 . 32433540 . 7264306 .
• Ronchese . F. . Hilligan . K. L. . Mayer . J. U. . 2020 . Dendritic cells and the skin environment . . 64 . 56–62. 10.1016/j.coi.2020.03.006 . 32387901 . 218584890 .
• Mayer . J. U. . Hilligan . K. L. . Chandler . J. S. . Ronchese . F. . etal . Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization . . 2021 . 22 . 12. 10.1038/s41590-021-01067-0. 1538–1550. 34795444 . 244402814 .

External links

• • • institutional homepage

Notes and References

1. Increasing the potency of dendritic cell based vaccines for the treatment of cancer . Open Access Te Herenga Waka-Victoria University of Wellington . 2014-01-01 . Doctoral . en . Dianne . Sika-Paotonu.
2. Web site: Professor Franca Ronchese . Malaghan . 31 January 2018.
3. Web site: Professor Franca Ronchese | Health Research Council . Hrc.govt.nz . 31 January 2018.
4. Web site: 2018-08-04. Franca Ronchese - The latest science on allergic reactions. 2020-10-19. RNZ. en-nz.
5. News: New Zealand scientific breakthrough could provide new allergy, asthma treatments. 25 January 2018 . 31 January 2018. The New Zealand Herald.
6. Web site: City scientists patent asthma breakthrough . Stuff.co.nz . 6 October 2014 . 31 January 2018.
7. Web site: Professor Franca Ronchese . Is Franca Ronchese the NEXT Woman of the Year 2012? . Malaghan . 31 January 2018.
8. Web site: Media. Gloss Creative. The Burnet Oration Australian and New Zealand Society for Immunology The premier scientific society for Immunology research in Australia and New Zealand.. 2020-10-19. www.immunology.org.au. en-US.
9. Web site: Finding a cancer cure is his holy grail . Stuff.co.nz . 2 June 2014 . 31 January 2018.