| François de Bourbon | |
| Count of Enghien | |
| Birth Date: | 23 September 1519 |
| Birth Place: | La Fère, Kingdom of France |
| Death Date: | 23 February 1546 |
| Death Place: | La Roche-Guyon |
| Noble Family: | Bourbon-Vendôme |
| Father: | Charles, Duke of Vendôme |
| Mother: | Françoise d'Alençon |
François de Bourbon, Count of Enghien (23 September 1519 – 23 February 1546) was a French prince du sang from the House of Bourbon-Vendôme, a cadet branch of the House of Bourbon (itself a cadet branch of the Capetian dynasty). He was the son of Charles de Bourbon, Duke of Vendôme and Françoise d'Alençon.
Given command of the French army in Italy by Francis I of France during the Italian War of 1542, he was the French commander at the successful Franco-Ottoman Siege of Nice in 1543, and he led it to victory at the Battle of Ceresole in a year later in 1544.
His early death at the age of 26 was caused by an accident – specifically by the falling of a heavy chest – in the castle La Roche-Guyon. He was succeeded as Count of Enghien by his younger brother John (Jean), who was also the Count of Soissons.