Fragilysin Explained

Fragilysin
Ec Number:	3.4.24.74
Cas Number:	188596-63-6

Fragilysin (Bacteroides fragilis (entero)toxin) is an enzyme.^{[1] [2] [3] [4] [5]} This enzyme catalyses the following chemical reaction

Broad proteolytic specificity, bonds hydrolysed including -Gly-Leu-, -Met-Leu-, -Phe-Leu-, -Cys-Leu-, Leu-Gly

It is thought to be a cause of diarrhoea in animals and humans.

Notes and References

1. Moncrief JS, Obiso R, Barroso LA, Kling JJ, Wright RL, Van Tassell RL, Lyerly DM, Wilkins TD . The enterotoxin of Bacteroides fragilis is a metalloprotease . Infection and Immunity . 63 . 1 . 175–81 . January 1995 . 7806355 . 172975 .
2. Obiso RJ, Lyerly DM, Van Tassell RL, Wilkins TD . Proteolytic activity of the Bacteroides fragilis enterotoxin causes fluid secretion and intestinal damage in vivo . Infection and Immunity . 63 . 10 . 3820–6 . October 1995 . 7558286 . 173537 .
3. Donelli G, Fabbri A, Fiorentini C . Bacteroides fragilis enterotoxin induces cytoskeletal changes and surface blebbing in HT-29 cells . Infection and Immunity . 64 . 1 . 113–9 . January 1996 . 8557328 . 173735 .
4. Koshy SS, Montrose MH, Sears CL . Human intestinal epithelial cells swell and demonstrate actin rearrangement in response to the metalloprotease toxin of Bacteroides fragilis . Infection and Immunity . 64 . 12 . 5022–8 . December 1996 . 8945541 . 174483 .
5. Kling JJ, Wright RL, Moncrief JS, Wilkins TD . Cloning and characterization of the gene for the metalloprotease enterotoxin of Bacteroides fragilis . FEMS Microbiology Letters . 146 . 2 . 279–84 . January 1997 . 9011050 . 10.1016/s0378-1097(96)00488-0 . free .