FOSL2 explained
Fos-related antigen 2 (FRA2) is a protein that in humans is encoded by the FOSL2 gene.[1]
Function
The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.[2]
See also
Further reading
- Matsui M, Tokuhara M, Konuma Y, Nomura N, Ishizaki R . Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation . Oncogene . 5 . 3 . 249–55 . March 1990 . 2107490 .
- Molven A, Houge G, Berger R . Chromosomal assignment of the human gene encoding the Fos-related antigen-2 (FRA2) to chromosome 2p22-p23 . Genomics . 38 . 1 . 72–5 . November 1996 . 8954781 . 10.1006/geno.1996.0593 .
- Outinen PA, Sood SK, Pfeifer SI, Pamidi S, Podor TJ, Li J, Weitz JI, Austin RC . Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells . Blood . 94 . 3 . 959–67 . August 1999 . 10419887 . 10.1182/blood.V94.3.959.415k20_959_967.
- Miyamoto NG, Medberry PS, Hesselgesser J, Boehlk S, Nelson PJ, Krensky AM, Perez HD . Interleukin-1beta induction of the chemokine RANTES promoter in the human astrocytoma line CH235 requires both constitutive and inducible transcription factors . Journal of Neuroimmunology . 105 . 1 . 78–90 . June 2000 . 10713367 . 10.1016/S0165-5728(00)00195-8 . 8547340 .
- Ng DC, Shafaee S, Lee D, Bikle DD . Requirement of an AP-1 site in the calcium response region of the involucrin promoter . The Journal of Biological Chemistry . 275 . 31 . 24080–8 . August 2000 . 10816578 . 10.1074/jbc.M002508200 . free .
- Bamberger AM, Milde-Langosch K, Rössing E, Goemann C, Löning T . Expression pattern of the AP-1 family in endometrial cancer: correlations with cell cycle regulators . Journal of Cancer Research and Clinical Oncology . 127 . 9 . 545–50 . September 2001 . 11570575 . 10.1007/s004320100255 . 7184971 .
- Udalova IA, Kwiatkowski D . Interaction of AP-1 with a cluster of NF-kappa B binding elements in the human TNF promoter region . Biochemical and Biophysical Research Communications . 289 . 1 . 25–33 . November 2001 . 11708771 . 10.1006/bbrc.2001.5929 .
- Benkoussa M, Brand C, Delmotte MH, Formstecher P, Lefebvre P . Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promoter . Molecular and Cellular Biology . 22 . 13 . 4522–34 . July 2002 . 12052862 . 133906 . 10.1128/MCB.22.13.4522-4534.2002 .
- Santalucía T, Christmann M, Yacoub MH, Brand NJ . Hypertrophic agonists induce the binding of c-Fos to an AP-1 site in cardiac myocytes: implications for the expression of GLUT1 . Cardiovascular Research . 59 . 3 . 639–48 . September 2003 . 14499865 . 10.1016/S0008-6363(03)00472-3 . free .
- Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proceedings of the National Academy of Sciences of the United States of America . 101 . 33 . 12130–5 . August 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . November 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
Notes and References
- Web site: Entrez Gene: FOSL2 FOS-like antigen 2.
- Web site: Entrez Gene: FOSL2 FOS-like antigen 2.
